PMID: 11035415Oct 18, 2000Paper

Renal immunofluorescence and the prediction of renal outcome in patients with proliferative lupus nephritis

Lupus
H NossentT Swaak

Abstract

The risk for endstage renal failure in patients with proliferative lupus nephritis (PLN) depends largely on the severity and reversibility of the inflammatory process as determined by light microscopy (LM). As the intrarenal formation of immune complexes is thought to initiate this inflammation, we studied whether renal immunofluorescence microscopy (IFM) provides clinical or prognostic information in addition to LM findings. Clinical data at the time of renal biopsy and during a mean follow-up of 46 months were extracted from the records of 69 SLE patients with proliferative LN (WHO class III/IV). Biopsy specimens were analyzed by LM for AI and CI, while IFM was performed on cryostat sections with the use of antisera against IgG, IgM, IgA, C3, C1q and fibrin. IFM findings were recorded in terms of the localization (glomerular, tubular or vascular) and intensity of fluorescence (score from zero to three). IFM findings were then related to clinical and LM findings and its prognostic value studied by survival analysis. Glomerular immune deposits were present in 99% of patients, tubular deposits in 38% and vascular deposits in 17%. A 'full-house' pattern (all three Ig classes) was found in 67% of biopsies and C3 and C1q deposits i...Continue Reading

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Citations

Aug 2, 2012·Annals of the Rheumatic Diseases·George K BertsiasUNKNOWN European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
Dec 23, 2015·Nature Immunology·Jill HenaultMiguel A Sanjuan
Sep 18, 2009·Annals of the New York Academy of Sciences·Renato Alberto SinicoGabriella Moroni
Dec 3, 2014·Diabetes Research and Clinical Practice·Koki MiseYoshifumi Ubara
Sep 18, 2012·Autoimmunity Reviews·Andrea T BorchersM Eric Gershwin
Feb 3, 2009·Molecular Immunology·Natalia PetrakovaMaria Isaguliants
Feb 18, 2003·Lupus·M Zabaleta-LanzN E Bianco

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