Renal impairment, hypertension and plasma urotensin II.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Ari MosenkisRaymond R Townsend

Abstract

Human urotensin II (UII) is a potent mammalian vasoconstrictor thought to be produced and cleared by the kidneys. Conflicting data exist regarding the relationship between UII concentrations, kidney function and blood pressure (BP). We measured the associations between kidney function [including end-stage renal disease (ESRD)] and levels of BP with plasma concentrations of UII. Ninety-one subjects were enrolled. Thirty-one subjects had ESRD (undergoing haemodialysis), 30 subjects had chronic kidney disease (CKD) and 30 control subjects had no kidney disease. Plasma UII concentrations were measured by radioimmunoassay. Mean plasma UII concentrations were highest in controls, lower in subjects with ESRD and lowest in subjects with non-ESRD CKD (P<0.0001). UII concentrations correlated negatively with serum creatinine (P=0.0012) and CKD stage, and positively with creatinine clearance (P=0.013). In ESRD subjects, plasma UII (P=0.008) increased after dialysis, while SBP (P=0.007), DBP (P=0.009), serum creatinine (P<0.0001) and serum urea nitrogen (P<0.0001) decreased. UII concentrations were lower in patients with a history of hypertension (HTN) (P=0.016). Age, race and gender did not appear to be associated with UII concentration. ...Continue Reading

References

Aug 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·D PearsonH A Bern
Dec 22, 1983·The New England Journal of Medicine·J M GinsbergS Garella
Dec 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V M BuckalewG Schulman
Mar 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M RahmanM C Smith
Sep 21, 2001·Lancet·K TotsuneO Murakami
Jan 12, 2002·British Journal of Pharmacology·Felix Böhm, John Pernow
Sep 21, 2002·Lancet·A Mark RichardsTimothy G Yandle
Nov 26, 2002·Journal of Hepatology·Jörg HellerTilman Sauerbruch
Dec 21, 2002·British Journal of Clinical Pharmacology·Jonathan T AffolterDavid J Webb
Jan 10, 2003·Clinical Science·Kazuhito TotsuneOsamu Murakami
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Harold I FeldmanUNKNOWN Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Dec 4, 2003·Biomaterials·Xiao Zheng ShuGlenn D Prestwich
Apr 23, 2004·Trends in Pharmacological Sciences·Stephen A DouglasDouglas G Johns
Jun 18, 2004·Journal of Hypertension·Bernard M Y CheungLouisa Y F Wong
Dec 17, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ayse BalatSaime Sahinoz
Apr 27, 2005·British Journal of Pharmacology·Stephen A DouglasDashyant Dhanak
May 4, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ozcan BalatRüksen Anarat
Mar 15, 2006·Kidney International·W SongN Ashton
Jun 30, 2006·Kidney International·N Ashton
Sep 5, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Yan-Xia WangYi-Chun Zhu
Nov 30, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ari MosenkisRaymond R Townsend
Jan 31, 2007·American Journal of Hypertension·Toshiaki SuguroMitsuru Adachi
Mar 17, 2007·Current Hypertension Reports·Henry Krum, Will Kemp
Oct 16, 2007·Peptides·Markus Tölle, Markus van der Giet
Jan 29, 2008·Cardiovascular & Hematological Agents in Medicinal Chemistry·A BalsamoS Rapposelli
Feb 14, 2008·Expert Opinion on Therapeutic Targets·Fernanda R C GiachiniR Clinton Webb
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Alaa E S Abdel-RazikNick Ashton

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Citations

Nov 22, 2011·Upsala Journal of Medical Sciences·Mehmet HursitogluAybala Erek
Dec 1, 2012·Current Opinion in Nephrology and Hypertension·Robyn G Langham, Darren J Kelly
Jan 18, 2017·International Journal of Hypertension·Fei WuChaoshu Tang
Nov 12, 2020·Clinical and Experimental Hypertension : CHE·Eray Metin GulerAbdurrahim Kocyigit

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