Renal infarction due to polyarteritis nodosa in a patient with angioimmunoblastic T-cell lymphoma: a case report and a brief review of the literature.

Diagnostic Pathology
Maria Raffaella AmbrosioSergio Tripodi

Abstract

Angioimmunoblastic T-cell lymphoma is one of the most common subtypes of peripheral T-cell lymphoma (15-20% of all cases), accounting for approximately 1-2% of all non-Hodgkin lymphomas. It often presents autoimmune phenomena including hemolytic anemia, thrombocytopenia, glomerulonephrities and circulating immune complexes. Polyarteritis nodosa is an autoimmune disease characterized by necrotizing vasculitis of medium vessels, which rarely develops in association with hematological malignant disorders. Herein we report the case of a 40-year-old man who underwent lymph node biopsy in the suspicious of sarcoidosis. On the basis of histological and immunohistochemical findings, the diagnosis of angioimmunoblastic T-cell lymphoma was performed. The patient was successfully treated with cytarabine-based regimen for 6 cycles. Three months after the initial diagnosis of angioimmunoblastic T-cell lymphoma, a whole body computed tomography showed a lesion in the lower pole of the left kidney. Renal cell carcinoma was suspected, thus a nephrectomy was carried out. The histological findings were compatible with polyarteritis nodosa. To the best of our knowledge, the association between polyarteritis nodosa and angioimmunoblastic T-cell ly...Continue Reading

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Citations

Mar 20, 2013·Journal of Medical Case Reports·Eleonora OrtuAnnalisa Monaco
Sep 13, 2013·Leukemia & Lymphoma·Sree Harsha TirumaniAnn S LaCasce
Jul 28, 2015·Current Medical Research and Opinion·Magali Van den BerghConstantin A Dasanu
Dec 20, 2015·International Journal of Surgery Case Reports·Fahd KhanSanjeev Madaan
Jun 24, 2017·The Journal of International Medical Research·Ti ZhangHuji Xu
May 27, 2017·Clinical Reviews in Allergy & Immunology·Francois Chasset, Camille Francès

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Methods Mentioned

BETA
X-ray
biopsy
PCR
light microscopy

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