PMID: 16615676Apr 18, 2006Paper

Renal infarction during the use of rizatriptan and zolmitriptan: two case reports

Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists
Jessica A FultonRobert S Hoffman

Abstract

Rizatriptan and zolmitriptan are both used to relieve acute migraine and cluster headaches. The mechanism of action is similar to the other triptans, in that they reverse abnormal cerebral vasodilation through their activity as 5-HT1B receptor agonists. Triptan-induced vasoconstriction is attributed to its activity on peripheral 5-HT1B receptors and has rarely been reported to result in stroke, myocardial infarction and ischemic colitis. We present two cases of renal infarction associated with therapeutic triptan use. The first patient is a 57-year-old man with a history of hypertension that was well controlled on valsartan and hydrochlorothiazide. He was recently diagnosed with cluster headaches and was treated with indomethacin, prednisone, butalbital-acetaminophen-caffeine and hydrocodone without relief. He then received two therapeutic doses of rizatriptan on each of the two days prior to presentation. Subsequently, he presented to the emergency department complaining of nausea, vomiting and right-sided abdominal pain. A computerized tomography (CT) scan of the abdomen and pelvis with intravenous contrast revealed a very large wedge shaped infarction of the right kidney. The second patient is a 34-year-old man with a past m...Continue Reading

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Citations

Dec 5, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shree G SharmaGlen Markowitz
Feb 7, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·I LarivièreM Mathieu-Nolf
Jul 23, 2008·Neuropharmacology·Antoinette MaassenVanDenBrinkCarlos M Villalón
Oct 2, 2008·Neurological Research·Debra Elliott
Jan 20, 2017·Advanced Pharmaceutical Bulletin·Javad Khalili FardMohammad Ali Eghbal
Oct 12, 2019·Canadian Journal of Physiology and Pharmacology·Parnia MobasheranHamed Shafaroodi
Jun 8, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Lingling HanJiang Zheng

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