Renal injury progression in autosomal dominant polycystic kidney disease: a look beyond the cysts

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Vasileios RaptisPantelis A Sarafidis

Abstract

Hypertension and progressive decline of renal function are among the common clinical manifestations in autosomal dominant polycystic kidney disease (ADPKD). At present, cyst formation in ADPKD patients is still considered the main pathogenic mechanism for the onset of these manifestations. However, the presence of polycystins in the vessels and the cilia of the endothelial cells and vascular smooth muscle cells, as well as development of hypertension prior to renal function decline and its prognostic role for the latter, indicate that polycystins may have an important role for endothelial damage in several vascular beds. Pathological polycystins induce intracellular calcium abnormalities, which affect various cellular organelles and functions and possibly lead not only to several abnormal biochemical reactions within endothelial cells, but also to an imbalance between oxidant and antioxidant capacity. Among the consequences of this process is accumulation of asymmetric-dimethylarginine, which not only participates in the induction and progression of renal damage, but also interferes with the normal vascular response due to nitric oxide (NO) inhibition. Reduced NO bioavailability would result in the long-run in relative vasocons...Continue Reading

References

Jul 1, 1992·Nature Genetics·S T Reeders
Jan 1, 1992·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L W ElzingaW M Bennett
Oct 18, 1990·The New England Journal of Medicine·A B ChapmanR W Schrier
Jun 1, 1988·Kidney International·P C Graham, G B Lindop
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·O A IakoubovaD R Beier
Aug 10, 1999·The Journal of Pathology·D J PetersE de Heer
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·K KimM A Arnaout
May 4, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I YoshidaV E Torres
Apr 17, 2001·Biochemical and Biophysical Research Communications·X Z ChenJ Zhou
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·C BoulterR Sandford
Feb 2, 2002·Human Molecular Genetics·A PersuO Devuyst
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew D PatersonYork Pei
Aug 23, 2002·Journal of the American Society of Nephrology : JASN·Peter Igarashi, Stefan Somlo
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Cauveh EramiJames E Faber
Apr 5, 2003·Kidney International·Muna A Al-NimriSharon Anderson
Oct 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Olivier DevuystMinh-Truc Vo-Cong
Oct 11, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marjan A van DijkRudi G J Westendorp
Mar 17, 2004·The Journal of Cell Biology·Carlo IominiGianni Piperno
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Peter J Blankestijn
May 7, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Alfonso RamunniPasquale Coratelli
May 8, 2004·American Journal of Physiology. Renal Physiology·Horacio F Cantiello
Jun 10, 2004·American Journal of Physiology. Renal Physiology·Mahmoud Loghman-AdhamLisa Cassis
Oct 22, 2004·Human Molecular Genetics·Irma S Lantinga-van LeeuwenDorien J M Peters
Oct 30, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dan WangSvend Strandgaard
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher S Wilcox
Aug 26, 2006·Nature Clinical Practice. Nephrology·Vicente E Torres, Peter C Harris
Nov 10, 2006·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Catherine R LawsonGraham A MacGregor
Apr 25, 2007·Néphrologie & thérapeutique·Jan T Kielstein, Danilo Fliser
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jared J GranthamVicente E Torres
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Elizabeth DicksPatrick S Parfrey
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Vicente E TorresUNKNOWN Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP)
Dec 8, 2007·American Journal of Nephrology·Ioannis KaramouzisDimitrios M Grekas
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dan WangChristopher S Wilcox

❮ Previous
Next ❯

Citations

Jul 26, 2018·Journal of the American Society of Nephrology : JASN·Yang YangChanglin Mei
Feb 20, 2020·Expert Opinion on Pharmacotherapy·Charalampos Loutradis, Pantelis Sarafidis
Dec 15, 2019·Seminars in Nephrology·Marieta TheodorakopoulouPantelis Sarafidis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
P McEwanK O'Reilly
Current Hypertension Reviews
Ashraf M MohieldinWissam A AbouAlaiwi
Advances in Chronic Kidney Disease
A B ChapmanFrederic Rahbari-Oskoui
© 2022 Meta ULC. All rights reserved