Renal interstitial expansion in insulin-dependent diabetes mellitus

Kidney International
P H LaneS M Mauer

Abstract

Eighty-four patients with insulin-dependent diabetes mellitus had studies of renal function and quantitative renal morphometry including mesangial volume fraction (Vvmes/glom), index of arteriolar hyalinosis, percentage of globally sclerosed glomeruli (%GS), and interstitial volume fraction for total renal cortex (Vvint/T). There was significant correlation among these four parameters, and all four structural parameters correlated with glomerular filtration rate and the log of urinary albumin excretion. Stepwise multiple regression analysis showed that Vvmes/glom and Vvint/T were additive, suggesting that they are partially independent. Arteriolar hyalinosis and %GS did not improve the correlations further. We hypothesize that Vvmes/glom, Vvint/T, arteriolar hyalinosis, and %GS represent multiple but probably interrelated pathologic mechanisms leading to the functional disturbances of diabetic nephropathy. Longitudinal studies of patients with diabetes and studies of patients with diseases producing interstitial expansion in the absence of glomerular disease may help clarify the independent role of interstitial expansion in the kidney disease of diabetes mellitus.

References

Jan 1, 1979·Journal of Microscopy·E B JensenR Osterby
Mar 1, 1991·Kidney International·K V Lemley, W Kriz
Apr 13, 1989·The New England Journal of Medicine·B M ChaversS M Mauer
Apr 1, 1986·Kidney International·E N EllisS M Mauer
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·J C Møller, E Skriver
Jun 1, 1984·Diabetologia·E R MathiesenT Deckert
Oct 1, 1984·The Journal of Clinical Investigation·S M MauerF C Goetz
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
May 1, 1982·Kidney International·K HiroseH J Gundersen

❮ Previous
Next ❯

Citations

Mar 31, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Clifford E KashtanUNKNOWN Alport Syndrome Research Collaborative
Oct 11, 2008·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Quansheng WangZhonghua Zhu
May 31, 2012·Current Diabetes Reports·Anil Karihaloo
Jul 22, 1999·Diabetes Research and Clinical Practice·K InaY Fujikura
May 22, 2002·European Journal of Internal Medicine·Masao KanauchiToshio Hashimoto
Sep 16, 2000·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D LandauD LeRoith
Nov 4, 2010·Nature Reviews. Nephrology·Takahiko NakagawaQiuhong Li
Aug 28, 2003·Clinical and Experimental Pharmacology & Physiology·Ho Jae HanJang Hern Lee
Dec 10, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·S C JonesC A Pollock
Nov 13, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·K E WhiteUNKNOWN Diabiopsies Group
Aug 5, 1999·Kidney International·G Wolf, F N Ziyadeh
Nov 13, 2001·Kidney International·G S HillJ Bariéty
Apr 25, 2001·Kidney International·B Rodríguez-IturbeR J Johnson
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Young Eun ChoiKyung Ah Park
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel LandauYael Segev
Jun 3, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hye Won ParkMichael Mauer
Apr 27, 1996·Transplantation·M E PagtalunanT W Meyer
Nov 18, 1998·Current Opinion in Nephrology and Hypertension·P FiorettoM Mauer
Apr 23, 2011·Journal of the American Society of Nephrology : JASN·Kumar SharmaJeffrey B Kopp
Mar 5, 2013·Archives of Pathology & Laboratory Medicine·Kirtee RapariaYashpal S Kanwar
Jul 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·W B Reeves, T E Andreoli
Mar 20, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Maryam Afkarian
Aug 27, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Lan HeYuhao Li
Oct 11, 2008·Scandinavian Journal of Clinical and Laboratory Investigation·Hans-Jacob BangstadKristian F Hanssen
Nov 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F N Ziyadeh
Oct 3, 2012·Diabetes Research and Clinical Practice·Jong Hee ParkHunjoo Ha
Oct 1, 1993·Kidney International·A K SharmaA F Michael
Nov 5, 1997·Kidney International·J MelinB C Fellström

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.