Renal involvement in Castleman disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Khalil El KarouiEric Daugas

Abstract

Castleman disease (CD), or angiofollicular lymph-node hyperplasia, is an atypical lymphoproliferative disorder with heterogeneous clinical manifestations. Renal involvement in CD has been described in only single-case reports, which have included various types of renal diseases. Nineteen patients with histologically documented CD and renal biopsies available were included. Clinical features and renal histological findings were reviewed, and the available samples were immunolabelled with anti-vascular endothelial growth factor (VEGF) antibody. Nineteen CD cases were identified: 89% were multicentric, and 84% were of the plasma-cell or mixed type. Four cases (21%) were associated with human immunodeficiency virus (HIV) infection. Among HIV-negative patients, two main patterns of renal involvement were found: (i) a small-vessel lesions group (SVL) (60%) with endotheliosis and glomerular double contours in all patients and with superimposed glomerular/arteriolar thrombi or mesangiolysis in most; and (ii) AA amyloidosis (20%). Renal histology was more heterogeneous among HIV-positive patients. Decreases in glomerular VEGF were observed only in some patients with SVL, whereas VEGF staining was normal in all other histological groups....Continue Reading

References

Aug 1, 1990·The Journal of Clinical Investigation·S J BrandtA W Nienhuis
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S SuematsuT Kishimoto
Sep 1, 1985·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G FrizzeraA Goldman
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J WeberD Cole
Feb 1, 1995·Internal Medicine·K TanakaT Ishida
Mar 1, 1995·Annals of Internal Medicine·K M BobergM Vatn
Mar 1, 1995·Annals of Internal Medicine·I KazesC Jacobs
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T ArinsoyS Sindel
Oct 12, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M SoubrierP Deteix
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y NakamotoA B Miura
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K KevenA E Ertuğ
Feb 7, 2001·Journal of the American Society of Nephrology : JASN·Jean BariétyAlain Meyrier
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Svetlana KarieGilbert Deray
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hervé SarteletPhilippe Rieu
Mar 25, 2006·Kidney International·O ThaunatA Karras
May 31, 2007·Current Opinion in Hematology·Anu Dham, Bruce A Peterson
Jun 8, 2007·The New England Journal of Medicine·Helen J LachmannPhilip N Hawkins
Sep 14, 2007·Blood Reviews·Angela Dispenzieri
Mar 14, 2008·The New England Journal of Medicine·Vera EreminaSusan E Quaggin
Jun 13, 2008·Kidney International·M Barry StokesVivette D D'Agati

❮ Previous
Next ❯

Citations

May 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Damin XuHong Zhang
Nov 23, 2012·BMC Nephrology·Oliver JungMarkus Bickel
Nov 5, 2011·Journal of the American Society of Nephrology : JASN·Khalil El KarouiDominique Nochy
Jul 17, 2013·Internal Medicine·Aya ImafukuYoshifumi Ubara
Aug 9, 2011·Clinical and Experimental Nephrology·Xiang-Gui YuanXiao-Ying Zhao
Dec 12, 2012·Revue des maladies respiratoires·R BorieL-J Couderc
Apr 9, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Kaoru MurakamiOsamu Ogawa
Sep 19, 2016·La Revue de médecine interne·A PaisM Ponsoye
Nov 9, 2016·Modern Rheumatology·Gen NakamuraNorihito Nakagawa
May 17, 2018·CEN Case Reports·Toshikazu OzekiShoichi Maruyama
Sep 25, 2017·CEN Case Reports·Shinsuke IsobeHideo Yasuda
Dec 14, 2011·Current Opinion in Rheumatology·Theresa W MuskardinJerry A Molitor
Feb 12, 2017·BMC Nephrology·Anubha MutnejaYing Maggie Chen
Mar 30, 2017·World Journal of Clinical Cases·Eray ErogluOktay Oymak
Nov 26, 2015·The American Journal of Surgical Pathology·Takeshi ZoshimaMitsuhiro Kawano
Oct 12, 2017·Frontiers in Medicine·Céline LouisYannick D Muller
Nov 11, 2019·BMC Nephrology·Muhammed HassenMohammed Rafique Moosa
Oct 19, 2019·BMC Nephrology·Yoshikuni NagayamaKatsuyuki Matsui
May 12, 2019·CEN Case Reports·Hirotaka SaitoJunichiro James Kazama
Nov 25, 2020·BMJ Case Reports·Julie SemenchukVishal Kukreti
Jan 25, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kazunori KarasawaTakahito Moriyama
Mar 2, 2021·British Journal of Hospital Medicine·Oscar SwiftBarbara Thompson
Dec 10, 2019·Urology·Lydia GlickCostas D Lallas
Jul 3, 2021·International Journal of Molecular Sciences·Kun-Hua TuHuang-Yu Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Castleman Disease

Castleman disease is a rare disorder that involves an overgrowth of cells in the lymph nodes. Unicentric Castleman disease affects one lymph node, usually in the chest or abdomen. Multicentric Castleman disease affects multiple lymph nodes, commonly located in the neck, collarbone, underarm and groin areas. Discover the latest research on Castleman disease here.