Renal involvement in childhood-onset systemic lupus erythematosus in Egypt.

Rheumatology International
Samia Salah-El-Din MahmoudDoaa Mohamed Abd-El-Aziz

Abstract

Lupus nephritis has been described as the most serious complication of systemic lupus erythematosus (SLE) and the strongest predictor of poor outcome. While the incidence of childhood SLE is relatively low, renal involvement appears to be more common and more severe in childhood SLE. This study aims to characterize the features and outcome of renal involvement in childhood-onset SLE based on a study of 100 Egyptian patients (mean age at diagnosis 10.1 years, range 2-17 years). Initial data regarding disease manifestations and biopsy findings were reviewed. Disease activity was assessed using SLEDAI scores. Follow-up data (mean duration 6 years) were noted regarding specific treatment, response, complications and renal survival. Initial renal involvement was present in 78 patients, including 66 with hypertension and 23 with renal impairment. Pathologically, class IV nephropathy was found in 18 patients, class V in 9 and low-grade lesions (class II-III) in 49. Twenty patients required follow-up biopsy, and all transformations were observed. SLEDAI scores significantly decreased from initial (mean ± SD) of 21.4 ± 7.3 to 13.4 ± 7.8, in association with response to therapy (P < 0.0001). Poor response was associated with initial hype...Continue Reading

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Citations

Jan 25, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Barbara RuggieroFrancesco Emma
Dec 14, 2011·Pediatric Rheumatology Online Journal·Samia SalahNouran Fahmy
Dec 11, 2014·Journal of Nephrology·Atef ElmougyAshraf Bakr
Sep 18, 2012·Autoimmunity Reviews·Andrea T BorchersM Eric Gershwin
May 25, 2016·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Juan S Calle ToroGabriel Tobon

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