Renal involvement in primary Sjogren's syndrome: a prospective cohort study

Rheumatology International
Ankit JainVir Singh Negi

Abstract

The objective of the study is to prospectively evaluate the spectrum of clinical and subclinical renal involvement in patients with primary Sjogren's syndrome (pSS). Of the 174 patients screened, seventy patients with pSS underwent renal function tests, urine examination, renal ultrasound, arterial blood gases, urine pH followed by urine acidification test and renal biopsy (if indicated). Renal tubular acidosis (RTA) was treated with alkali replacement and moderate-severe tubulointerstitial nephritis (TIN) was treated with oral prednisolone. Sixty-two patients completed 1-year follow-up. A comparison was made between patients with and without renal involvement. Thirty-five (50%) patients had renal involvement. They had a lower baseline eGFR (71.85 ± 18.04 vs. 83.8 ± 17, p = 0.005). Twenty-nine patients had RTA (25 complete and 4 incomplete). Eleven patients had urinary abnormalities. Patients with RTA (n = 29) were younger (34.9 ± 9 vs. 42 ± 11.3, p = 0.006), had fewer articular (34% vs. 78%, p = 0.001) and ocular sicca (62% vs. 88%, P = 0.01) than those without RTA (n = 41) and commonly presented with hypokalemic paralysis. On biopsy, TIN (9/17) and IgA nephropathy (3/17) were most common. On follow-up, there was no clinically...Continue Reading

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Citations

Aug 21, 2020·International Journal of Rheumatic Diseases·Qian Wang, Sheng-Ming Dai
Jun 13, 2020·Journal of Nephrology·Claudio PonticelliGabriella Moroni
Jul 28, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Aurélia Bertholet-ThomasLuc-André Granier
Jan 4, 2021·Rheumatology International·Sakir AhmedOlena Zimba
Dec 17, 2020·Frontiers in Medicine·Ruping HongXiaofeng Zeng
Dec 29, 2020·Rheumatology and Therapy·Oshorenua AiyegbusiKathryn I Stevens
Jul 6, 2021·International Journal of Rheumatic Diseases·Ruiying ChenChuanming Hao

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