Renal ischemia-reperfusion injury: new implications of dendritic cell-endothelial cell interactions

Transplantation Proceedings
C L SchlichtingM Weis

Abstract

In renal ischemia/reperfusion (I/R) injury endothelial cells are a main target. The disturbance of endothelial cell physiology leads to endothelial swelling and narrowing of the blood vessel lumen. We attribute this effect to impairment of endothelial cell nitric oxide synthase (NOS). NO is significantly reduced in the course of hypoxia causing dysfunction of the vascular smooth muscle tone. Subsequently to an I/R injury, the inflammatory response results in endothelial activation with enhanced dendritic cell (DC) adhesion and migration. Thus, alloreactive leukocytes are recruited to the inflammatory site. Finally, dendritic cell-endothelial cell interactions may play a crucial role in antigen-specific allograft rejection in I/R renal injury. DCs, which activate naïve alloreactive T cells, play a central role in the establishment of alloantigen-specific immunity. In the course of hypoxia rejection is initiated at the activated layer of foreign endothelial cells (EC), which forms an immunogenic barrier for migrating DCs and T cells. Host DCs that bind to postischemic activated ECs invade the allografted tissues, or remain stationary in the subendothelial layer, or transmigrate into lymphoid vessels and secondary lymphoid organs,...Continue Reading

References

Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·T Wakabayashi, H Onoda
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Jan 1, 1972·The Journal of Clinical Investigation·J FloresA Leaf
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
Mar 21, 1998·Transplant Immunology·M L Foegh, P W Ramwell
May 16, 1998·Transplantation·L SonderbyeE Langhoff
May 26, 1999·Infectious Disease Clinics of North America·T van der Poll, S J van Deventer
Sep 1, 1999·Kidney International·L C Paul
Apr 25, 2000·Annual Review of Medicine·M Weis, W von Scheidt
Jun 24, 2000·The New England Journal of Medicine·C Parikh, D H Ellison
Nov 17, 2001·International Immunopharmacology·K A Brown
May 9, 2002·American Journal of Physiology. Renal Physiology·Sergey V BrodskyMichael S Goligorsky
Aug 24, 2002·Circulation Research·Göran K HanssonZhong-Qun Yan
Apr 10, 2003·American Journal of Physiology. Renal Physiology·Timothy A SuttonBruce A Molitoris
May 9, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Douglas D Bannerman, Simeon E Goldblum
Oct 8, 2003·Transplantation Proceedings·J SieńkoA Mizerski
Jan 14, 2004·Kidney International·Abdulla K SalahudeenWarren May
Dec 24, 2004·The New England Journal of Medicine·Mohamed H Sayegh, Charles B Carpenter
Aug 24, 2005·Journal of Cardiovascular Pharmacology·Christoph L SchlichtingMichael Weis

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Citations

Nov 27, 2008·Transplantation·Rafia S Al-LamkiJordan S Pober
Jul 30, 2009·The Tohoku Journal of Experimental Medicine·Honglin HuCarole Nicco
Aug 28, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Carla Q FeitozaNiels Olsen Saraiva Câmara
Apr 25, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Arunachalam MuthuramanAjay Rana
Apr 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Myung-Gyu KimSang-Kyung Jo
Jun 30, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hye Ryoun JangHamid Rabb
Feb 29, 2008·Immunopharmacology and Immunotoxicology·Kyung-Eun KimJong-Wan Park
Oct 17, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hye Ryoun Jang, Hamid Rabb
May 13, 2008·The Journal of Surgical Research·Alexander M GorbachEric A Elster
Aug 5, 2010·International Journal of Experimental Pathology·Katharina HochheiserChristian Kurts
Oct 19, 2007·Cellular Immunology·Yanfei HuangKarl L Womer
Apr 30, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Swasti Chaturvedi, Lisa A Robinson
Oct 22, 2014·Nature Reviews. Nephrology·Hye Ryoun Jang, Hamid Rabb
Dec 24, 2010·World Journal of Cardiology·Yi Zhang, Cuihua Zhang
Sep 13, 2018·American Journal of Physiology. Renal Physiology·Yoshikazu MuroyaRichard J Roman
Jul 19, 2008·Anesthesia and Analgesia·Michael P HutchensPer O Jarnberg
Jan 4, 2008·American Journal of Physiology. Renal Physiology·John BylanderJudith S Bond
May 7, 2020·Nature Reviews. Nephrology·Christian KurtsUlf Panzer
Apr 5, 2018·Cardiorenal Medicine·Grazia Maria VirzìPeter A McCullough
Jun 8, 2021·Frontiers in Immunology·Jinwen LinJianghua Chen

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