Renal lesions in rhabdomyolysis caused by Pseudechis australis snake myotoxin

Kidney International
D Ponraj, P Gopalakrishnakone

Abstract

The renal lesions at various time intervals after i.m. injection of Pseudechis australis myotoxin (PA myotoxin) causing myoglobinuria in mice was studied. Biochemical assay of serum creatine phosphokinase (CK) and lactate dehydrogenase (LDH) showed marked elevations [7166 +/- 2064 IU and 1626 +/- 211 Berger-Broida U/ml (B-B U/ml)] six hours after injection, indicative of rhabdomyolysis. Serum creatinine (1.6 +/- 0.39) and urea (147 +/- 40) showed significant rise by 48 hours indicative of acute renal failure (ARF). Immunodiffusion showed the presence of myoglobin in the urine (myoglobinuria) of experimental animals. Light microscopic (LM) and scanning electron microscopic (SEM) studies of the urinary sediments from experimental mice revealed granular casts of varying size and shape. LM of kidney showed casts from one hour and tubulopathy with degenerated tubular epithelial cell from 12 hours onwards. Focal glomerular changes, such as dilated Bowman's space with poorly stained substance and reduction in number of glomerular tufts were observed. Immunofluorescence microscopy for myoglobin showed fluorescence of the casts in the tubules. Transmission electron microscopy (TEM) showed electron dense casts occupying the entire lumen ...Continue Reading

References

Jan 1, 1979·Toxicon : Official Journal of the International Society on Toxinology·T M LeonardiI Spence
Jan 1, 1978·Toxicon : Official Journal of the International Society on Toxinology·M Aung-Khin
Jan 1, 1992·Kidney International·F G Toback
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·C TakasakiN Tamiya
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology· Soe-Soe Khin-Ei-Han
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·E G RowanN Tamiya
Apr 20, 1968·The Medical Journal of Australia·M A Furtado, I A Lester
Feb 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·L P Rowland
Jun 1, 1983·Kidney International·N Honda
May 1, 1982·Medicine·P A GabowS P Kelleher
Jul 1, 1982·The Journal of Pathology·A Date, J C Shastry
Jan 1, 1980·Toxicon : Official Journal of the International Society on Toxinology·D Mebs, Y Samejima
Jan 1, 1995·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M Abul FaizD Mantle
Jan 1, 1994·Ultrastructural Pathology·G A Herrera
May 1, 1996·Current Opinion in Nephrology and Hypertension·J V Bonventre, R B Colvin
Feb 1, 1996·Kidney International·R A Zager
May 6, 1961·British Medical Journal·H A REID

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Citations

Sep 25, 2008·Nature Clinical Practice. Nephrology·Visith Sitprija
Sep 15, 2001·The New England Journal of Medicine·R BedryJ Beylot
Feb 26, 2005·Clinical and Experimental Pharmacology & Physiology·Sharmaine RamasamyWayne C Hodgson
Jun 17, 2003·Journal of Toxicology. Clinical Toxicology·Julian WhiteGeoffrey K Isbister
Jun 19, 2014·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A J HartG K Isbister
Jun 19, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V Sitprija, P Gopalakrishnakone
Aug 10, 2011·Toxicon : Official Journal of the International Society on Toxinology·T E Jacoby-AlnerK Swindells
Jul 16, 2008·Seminars in Nephrology·Talerngsak Kanjanabuch, Visith Sitprija
Oct 4, 2006·Nephrology·Visith Sitprija
Nov 9, 2004·Toxicon : Official Journal of the International Society on Toxinology·Sharmaine RamasamyWayne C Hodgson
Dec 3, 2011·Toxicon : Official Journal of the International Society on Toxinology·Adolfo Rafael de RoodtRoberto Pablo Stock
Jul 4, 2012·Toxicon : Official Journal of the International Society on Toxinology·Visith Sitprija, Siravit Sitprija
Dec 19, 2012·Toxicon : Official Journal of the International Society on Toxinology·Andrew J HartWayne C Hodgson
Mar 21, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Mongkon CharoenpitakchaiJaneyuth Chaisakul
Feb 4, 2003·Seminars in Nephrology·Visith Sitprija
Feb 5, 2000·Neurologic Clinics·W S David

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