Renal-limited vasculitis with elevated levels of multiple antibodies

CEN Case Reports
Noriaki SatoMotoko Yanagita

Abstract

Renal-limited vasculitis (RLV) is a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis that presents with crescentic glomerulonephritis with no other organ involvement. Although several studies reported patients with crescentic glomerulonephritis who were dual positive for proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA or ANCA and anti-glomerular basement membrane (GBM) antibody, patients positive for all three antibodies, i.e., triple-positive patients, were rarely reported. We herein report the case of a male with pauci-immune type crescentic glomerulonephritis positive for MPO-ANCA, PR3-ANCA, and anti-GBM antibody. Renal biopsy led to the definitive diagnosis of RLV with pauci-immune-type crescentic glomerulonephritis. Fluorescence immunostaining showed no linear deposition of IgG on GBM, indicating no involvement of anti-GBM associated diseases. Intensive therapy, including prednisolone, plasma exchange, and intravenous cyclophosphamide, was effective. We report the case of triple-positive patient with crescentic glomerulonephritis, who was successfully treated with glucocorticoid, plasma exchange, and cyclophosphamide, suggesting that treatment for RLV in the patient with serological triple a...Continue Reading

References

Jan 12, 2002·Kidney International·Herbert A HauerUNKNOWN European Vasculitis Study Group (EUVAS)
Jun 20, 2003·The New England Journal of Medicine·Billy G HudsonEric G Neilson
Apr 8, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sven WeidnerHarald D Rupprecht
Oct 2, 2004·Kidney International·Jeremy B LevyCharles D Pusey
Aug 23, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Abraham RutgersJan Willem Cohen Tervaert
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Elena CsernokWolfgang L Gross
Jun 22, 2007·Journal of the American Society of Nephrology : JASN·David R W JayneUNKNOWN European Vasculitis Study Group
Jun 18, 2009·Clinical and Experimental Nephrology·Akio KoyamaUNKNOWN Japan RPGN Registry Group
Nov 13, 2010·Kidney & Blood Pressure Research·Shigeto KobayashiKazuo Suzuki
Aug 27, 2011·Journal of the American Society of Nephrology : JASN·Stephen W OlsonChristina M Yuan
Apr 15, 2014·Rheumatology·Eleana NtatsakiUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Oct 18, 2014·Journal of the American Society of Nephrology : JASN·Michael J KemnaJan Willem Cohen Tervaert
Nov 15, 2014·PloS One·Laura M StintonMarvin J Fritzler
Jan 23, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bassam AlchiKen Farrington
Apr 22, 2016·Clinical and Experimental Nephrology·Yoshihiro ArimuraSeiichi Matsuo

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