PMID: 7033435Dec 1, 1981Paper

Renal localization of the membrane attack complex in systemic lupus erythematosus nephritis

The Journal of Experimental Medicine
G BieseckerD Koffler

Abstract

The membrane attack complex (MAC) of the complement system was localized in both glomeruli and peritubular regions of 22 kidneys manifesting systemic lupus erythematosus (SLE) nephritis. A similar distribution was observed for immune complex markers (IgG, Clq, and C3) and MAC in glomeruli, although the deposits of MAC were more discrete and showed lesser immunofluorescence staining intensity compared with immunoglobulins and complement components. In contrast, peritubular immune complexes were present in only 7 out of 22 kidneys, involved comparatively small clusters of tubules, exhibited weaker immunofluorescence staining than MAC, and failed to correlate with interstitial foci of inflammation. Granular or irregular, linear aggregates of the MAC were observed at the periphery of larger groups of tubules contiguous to areas of interstitial inflammation. Comparable amounts of IgG, Clq, C3, and MAC were present in blood vessel walls in areas of fibrinoid necrosis. These data suggest that the MAC is a direct mediator of tissue injury occurring in renal glomeruli, tubules, and blood vessels. The discordance between immune complexes and MAC localized in the peritubular region, but not in glomeruli or blood vessels, raises the possib...Continue Reading

References

May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·W P Kolb, H J Müller-Eberhard
Mar 12, 1977·Lancet·R J LevinskyJ F Soothill
Apr 1, 1975·Kidney International·G A Andres, R T McCluskey
Jan 1, 1975·Annual Review of Biochemistry·H J Müller-Eberhard
Feb 1, 1973·Kidney International·V AgnelloH G Kunkel
Oct 1, 1967·The Journal of Experimental Medicine·D KofflerH G Kunkel
Mar 7, 1968·The New England Journal of Medicine·P H Schur, J Sandson
Jul 1, 1971·The Journal of Experimental Medicine·D KofflerH G Kunkel
Jan 1, 1967·The Journal of Experimental Medicine·E R UnanueJ D Feldman
Nov 1, 1980·The Journal of Clinical Investigation·R N PinckardM S Olson
Dec 1, 1980·The Journal of Clinical Investigation·L Raptis, H A Menard
Jul 1, 1965·The Journal of Experimental Medicine·W T KNIKER, C G COCHRANE

❮ Previous
Next ❯

Citations

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·N AkanoS Maki
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·K Fujii, Y Kobayashi
Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·H MiyamotoS Maki
Jan 1, 1984·Springer Seminars in Immunopathology·H J Müller-Eberhard
Apr 1, 1997·Clinical Reviews in Allergy & Immunology·D D'CruzG Hughes
Dec 27, 1985·Journal of Immunological Methods·M E SandersK A Joiner
Aug 11, 1983·Biochimica Et Biophysica Acta·S Bhakdi, J Tranum-Jensen
Oct 1, 1988·The American Journal of Medicine·E L AlexanderK A Joiner
Jan 1, 1997·The Journal of Laboratory and Clinical Medicine·T F MüllerH Lange
Jul 17, 1999·Immunopharmacology·G BieseckerR A Bendele
Feb 4, 1982·The New England Journal of Medicine·G BieseckerD Koffler
Jul 8, 1982·The New England Journal of Medicine·R D Sontheimer, J N Gilliam
Feb 6, 1986·The New England Journal of Medicine·J T KisselK W Rammohan
Aug 21, 1986·The New England Journal of Medicine·J A SchifferliD K Peters
Jun 1, 1983·The Journal of Experimental Medicine·D KofflerA Martinez-Hernandez
Apr 1, 1995·Histopathology·T N Khan, R Sinniah
Dec 17, 2003·Kidney International·Margaret K ElliottGary S Gilkeson
Jan 28, 2005·Kidney International·Gopala K RanganWilliam G Couser
Mar 1, 1990·Journal of Clinical Pathology·A J HowieA J Niblett
Jun 16, 2012·Clinical & Developmental Immunology·Yi-Wen JiangDao-Feng Chen
Dec 1, 1983·The Journal of Clinical Investigation·G C GroggelD J Salant
Jun 23, 2011·International Journal of Nephrology and Renovascular Disease·Catherine ToongTri Giang Phan
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·A P Dalmasso
Feb 1, 1987·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R J FalkR L Vernier
Jan 15, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Brad H Rovin, Samir V Parikh
Sep 22, 2015·American Journal of Reproductive Immunology : AJRI·Manuela VegliaNicoletta Di Simone
Jan 1, 1993·Kidney International·H E Abboud
Oct 1, 1988·Kidney International·A B MagilR A Sutton
Jun 1, 1992·Kidney International·L D TruongD Gillum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.