Renal medulla and bradykinin during the development of hypertension in SHR

Clinical and Experimental Pharmacology & Physiology
J B O'SullivanS B Harrap

Abstract

1. The long-term reduction in blood pressure following ACE inhibitor treatment in young spontaneously hypertensive rats (SHR) appears to depend on both the kidney and bradykinin. 2. The aim of this experiment was to examine the effects of ACE inhibition and bradykinin on renal morphology and blood pressure in SHR. 3. Between 6 and 10 weeks of age male SHR received one of four treatments: water (n = 26), ramipril (1 mg/kg per day; n = 24), ramipril (1 mg/kg per day) plus Hoe 140 (0.5 mg/kg per day; n = 25) or Hoe 140 (0.5 mg/kg per day; n = 25). 4. Renal medullary and cortical volumes were determined stereologically at 10 and 20 weeks of age. 5. After 4 weeks of treatment, ramipril reduced the size of the renal medulla while Hoe 140 increased medullary volumes compared to control. Ten weeks after treatment was stopped the renal medulla of the ramipril group had returned to normal, however, there was a persistent increase in medullary volume of both Hoe 140 treated groups. 6. Our results imply that bradykinin may influence the size of the renal medulla which may have important effects on the development of hypertension in SHR.

References

Dec 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·A W CowleyD L Mattson
Sep 1, 1992·Journal of Hypertension·E E MuirheadL W Byers
Aug 1, 1991·Journal of Hypertension·Y H Ma, E W Dunham
Aug 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H SvanholmS Olsen
Oct 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenB Pakkenberg
May 12, 1994·European Journal of Pharmacology·M K Sim, R Radhakrishnan
May 23, 1994·European Journal of Pharmacology·B I Gustafsson, D S Delbro

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Citations

Jun 11, 1999·Japanese Journal of Pharmacology·A DendorferP Dominiak

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