Renal membrane transport of glutathione in toxicology and disease

Veterinary Pathology
Lawrence H Lash

Abstract

Membrane transport processes, at both the plasma membranes and intracellular membranes, play critical roles in renal function and are a determining factor in the susceptibility of renal epithelial cells to blood-borne drugs and toxic chemicals. Proximal tubular epithelial cells possess a large array of transport proteins for organic anions, organic cations, and peptides on both basolateral and brush-border plasma membranes. Although these transporters function in excretion of waste products and reabsorption of nutrients, they also play a role in the susceptibility of the kidneys to drugs and other toxicants in the blood. The proximal tubules are typically the primary target cells because they are the first epithelial cell population exposed to such chemicals in either the renal plasma or glomerular filtrate and because of their large array of membrane transporters. Besides transport across the basolateral and brush-border plasma membranes, transport across intracellular membranes such as the mitochondrial inner membrane is a critical determinant of metabolite distribution. To illustrate the function of these transporters, carrier-mediated processes for transport of the tripeptide and antioxidant glutathione across the basolater...Continue Reading

References

Feb 1, 1978·FEBS Letters·G M Bartoli, H Sies
Mar 20, 1978·Biochimica Et Biophysica Acta·R HahnL Flohé
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister
Jan 1, 1979·Methods in Enzymology·M Klingenberg
Aug 1, 1991·Archives of Biochemistry and Biophysics·T B McKernanL H Lash
Jan 1, 1991·Life Sciences·R G Schnellmann
Jul 1, 1990·Archives of Biochemistry and Biophysics·R S KaplanG L Wilson
Feb 28, 1990·Biochemical and Biophysical Research Communications·K KurosawaK Tagawa
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J MårtenssonA Meister
May 15, 1986·Archives of Biochemistry and Biophysics·L H Lash, D P Jones
Aug 15, 1986·Biochemical Pharmacology·P Graf, H Sies
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister
Jan 1, 1985·Annual Review of Physiology·A C Schoolwerth, K F LaNoue
Aug 1, 1985·Archives of Biochemistry and Biophysics·L H Lash, D P Jones
Jan 29, 1980·Biochemical and Biophysical Research Communications·K Ormstad, S Orrenius
Jan 1, 1980·The International Journal of Biochemistry·T M McIntyre, N P Curthoys
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M E Anderson, A Meister
Apr 15, 1983·Biochemical and Biophysical Research Communications·L H Lash, D P Jones
Dec 1, 1994·Environmental Health Perspectives·L H Lash
Jul 18, 1996·Biochimica Et Biophysica Acta·F PalmieriL Palmieri
Mar 1, 1997·Journal of the American Society of Nephrology : JASN·H N Ibrahim, T H Hostetter
Aug 23, 2000·Pflügers Archiv : European journal of physiology·T SekineH Endou
Jan 3, 2001·Kidney International·E B Berkhin, M H Humphreys
Mar 14, 2001·The Journal of Membrane Biology·R S Kaplan
Feb 5, 2002·Annual Review of Physiology·Frans G M RusselRemon A M H van Aubel
Feb 21, 2002·Biochimica Et Biophysica Acta·James F RebbeorNazzareno Ballatori
May 2, 2002·The Journal of Nutrition·Yuki UenoToshihiko Osawa
Nov 6, 2002·Biochemical Pharmacology·Lawrence H LashJudith P Horwitz

❮ Previous
Next ❯

Citations

Nov 5, 2013·BioMed Research International·Ankita UmapathyJulie Lim
Sep 6, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M Cecilia CirioNeil A Hukriede
Dec 9, 2014·Mutation Research. Reviews in Mutation Research·Lawrence H LashIvan Rusyn
Sep 1, 2012·Bulletin of Environmental Contamination and Toxicology·Rais A AnsariWilliam O Berndt
Aug 5, 2015·Journal of Clinical Medicine·Lawrence H Lash
Nov 18, 2014·International Journal of Molecular Sciences·Christopher RacineGary O Rankin
Nov 17, 2011·Toxicology and Applied Pharmacology·David A PuttLawrence H Lash
Sep 4, 2015·European Journal of Nutrition·José Alberto Conde-AguileraJaap van Milgen
Nov 20, 2013·Nephron. Physiology·Lena SchorbachBirgitta C Burckhardt
Dec 21, 2012·American Journal of Physiology. Renal Physiology·Yohannes HagosBirgitta C Burckhardt
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yi-Hui ZhouIvan Rusyn
Aug 14, 2019·Scientific Reports·Lyudmila KovalchukeLloyd A Greene
Mar 7, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Isabella Dalle-DonneAldo Milzani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.