Renal microvascular assembly and repair: power and promise of molecular definition

Kidney International
T TakahashiT O Daniel

Abstract

Developmental assembly of the renal microcirculation is a precise and coordinated process now accessible to experimental scrutiny. Although definition of the cellular and molecular determinants is incomplete, recent findings have reframed concepts and questions about the origins of vascular cells in the glomerulus and the molecules that direct cell recruitment, specialization and morphogenesis. New findings illustrate principles that may be applied to defining critical steps in microvascular repair following glomerular injury. Developmental assembly of endothelial, mesangial and epithelial cells into glomerular capillaries requires that a coordinated, temporally defined series of steps occur in an anatomically ordered sequence. Recent evidence shows that both vasculogenic and angiogenic processes participate. Local signals direct cell migration, proliferation, differentiation, cell-cell recognition, formation of intercellular connections, and morphogenesis. Growth factor receptor tyrosine kinases on vascular cells are important mediators of many of these events. Cultured cell systems have suggested that basic fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF) promote e...Continue Reading

References

Mar 1, 1988·Journal of Cellular Physiology·R MontesanoL Orci
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Antonelli-OrlidgeP A D'Amore
Jan 1, 1987·Differentiation; Research in Biological Diversity·L Saxén, E Lehtonen
Jan 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L LaitinenL Saxén
Jan 1, 1982·Cell Differentiation·P EkblomL Saxén
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·H KitamuraN Yamanaka
May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·D J DumontM L Breitman
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A OstmanN K Tonks
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T N SatoK L Audus
Sep 1, 1995·Current Biology : CB·A PandeyV M Dixit
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·A von HerbayJ Rudi
Nov 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G BreierW Risau
Jul 4, 1996·Nature·M W MooreA Rosenthal
Jan 1, 1995·Annual Review of Cell and Developmental Biology·W Risau, I Flamme
Sep 1, 1996·Kidney International·G B Fogazzi, J S Cameron
Sep 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G H FongM L Breitman
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Jan 1, 1996·Molecular and Cellular Neurosciences·I Mason

❮ Previous
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Citations

Dec 22, 1999·Hearing Research·W R van HeumenJ O Pickles
Jan 28, 2003·Drug Discovery Today·Petra BurgstallerMichael Blind
Sep 15, 1998·Kidney International. Supplement·D R AbrahamsonT O Daniel
Dec 15, 2000·Kidney International·G Remuzzi, A Benigni
Mar 13, 2003·Kidney International·Mitsuru NotoyaHidetake Kurihara
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·C Merlet-BénichouT Gilbert
Oct 8, 1999·The Journal of Clinical Investigation·T OstendorfJ Floege
May 16, 2009·Journal of the American Society of Nephrology : JASN·Yuji SekineKunimasa Yan
Jun 9, 2001·Biochemical and Biophysical Research Communications·Y Mizuno-HorikawaT Kurosawa
Jul 16, 2004·Kidney International·Maarten B RookmaakerTon J Rabelink
Oct 3, 1999·Kidney International·D R Abrahamson
Jul 24, 2003·The American Journal of Pathology·Maarten B RookmaakerMarianne C Verhaar
Nov 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A AmoreR Coppo
Feb 12, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mikhail V TsurkanCarsten Werner
May 21, 2015·World Journal of Experimental Medicine·Dodanim Talavera-Adame, Donald C Dafoe
Nov 4, 2008·Molecular Biology Reports·Sheng-Hua ChuJian-Hua Qiu
Jun 23, 2006·Journal of the American Society of Nephrology : JASN·Xiu-Bin LiangAgnes B Fogo
Mar 14, 2018·Journal of the American Society of Nephrology : JASN·David P Basile, Mervin C Yoder
Oct 2, 2003·American Journal of Physiology. Renal Physiology·Shinya Mizuno, Toshikazu Nakamura
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Wolfgang FierlbeckBarbara J Ballermann
Jun 26, 2001·Journal of the American Society of Nephrology : JASN·Toshiyuki ImasawaTsuneya Ohno
Sep 20, 2001·Journal of the American Society of Nephrology : JASN·Jing ShaoMasaomi Nangaku
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Takamune TakahashiThomas O Daniel
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·H T YuanA S Woolf
Oct 3, 1999·Journal of the American Society of Nephrology : JASN·T TakahashiT O Daniel

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