Renal microvascular constriction to membrane depolarization and other stimuli: pivotal role for rho-kinase

Pflügers Archiv : European journal of physiology
M H RoosGeert Jan Tangelder

Abstract

Contraction of vascular smooth muscle is determined not only by levels of intracellular free calcium but also by the sensitivity of its contractile apparatus. A potential modulator of the latter is rho-kinase. We addressed the question of a possible central role for rho-kinase in the regulation of periglomerular microvascular tone. In the rat hydronephrotic kidney model, diameter changes of distal interlobular arteries, afferent and efferent arterioles were measured using three distinctly different stimuli: intravascular pressure changes, angiotensin II (AngII) and membrane depolarization, which is a physiological component of many signaling pathways, as evoked in two ways. Two selective, structurally different rho-kinase inhibitors, Y-27632 and HA-1077, were employed, as well as a selective protein kinase C alpha inhibitor. Preglomerular vasoconstriction induced by direct membrane depolarization, increases in pressure or AngII all depended for their effect on rho-kinase. A differing role for rho-kinase in efferent arteriolar constriction to AngII as compared to preglomerular microvessels was not found. In conclusion, our data indicate that in the kidney, rho-kinase is involved in a variety of signaling pathways leading to micr...Continue Reading

References

Jun 1, 1983·Kidney International·M SteinhausenP C Johnson
Apr 1, 1995·The American Journal of Physiology·M T Nelson, J M Quayle
Oct 23, 1997·The Journal of Clinical Investigation·T TakenakaT Saruta
Sep 22, 2000·The Biochemical Journal·S P DaviesP Cohen
Feb 9, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Christa BoerPieter Sipkema
Jun 13, 2002·American Journal of Physiology. Renal Physiology·William F van RodijnenPiet M Ter Wee
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Alessandro CavarapeKarlhans Endlich
Aug 7, 2003·Journal of Vascular Research·Akira NakamuraTakao Saruta
Aug 26, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandro CavarapeNiranjan Parekh
Oct 18, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mitsuya ShiraishiRodger Loutzenhiser
Jul 31, 2004·Acta Physiologica Scandinavica·M SalomonssonN-H Holstein-Rathlou
Jan 4, 2005·American Journal of Nephrology·Ming-Guo Feng, L Gabriel Navar

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Citations

Jul 16, 2013·Current Hypertension Reports·Olaf Grisk
Aug 27, 2009·Biologics : Targets & Therapy·Lina NordquistBradley T Andresen
Nov 9, 2010·The Journal of Sexual Medicine·Serap GurWayne J G Hellstrom
Feb 9, 2012·International Journal of Cell Biology·Silvia Chifflet, Julio A Hernández
Feb 20, 2007·Circulation Research·Koichi HayashiTakao Saruta
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lina NordquistA Erik G Persson
Nov 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·John J RehoSteven A Fisher
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Sep 20, 2019·Journal of Cellular Physiology·Frances EvansSilvia Chifflet
Aug 23, 2019·American Journal of Physiology. Renal Physiology·Zhengrong GuanEdward W Inscho

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