PMID: 9533617Apr 9, 1998Paper

Renal nerves and D1-dopamine receptor-mediated natriuresis

Clinical and Experimental Hypertension : CHE
L D AsicoP A Jose

Abstract

The resistance of the spontaneously hypertensive rat (SHR) kidney to the natriuretic effect of dopamine and D1 agonists may be due to increased renal nerve activity. Therefore, we compared the effects of the intrarenal arterial infusion of the D1 agonist, SKF 38383, into the denervated (DNX) kidney of saline-loaded-anesthetized SHR and its control, the Wistar-Kyoto (WKY) rat. In both WKY and SHR, DNX of the left kidney slightly decreased urine flow (UV) and absolute (UNaV) and fractional sodium excretion (FENa) in the innervated right kidney; neither vehicle nor D1 agonist infusion exerted any effect. In the left kidney, denervation increased UV, UNaV, and FENa to a similar degree in WKY and SHR (2-fold), without affecting renal blood flow, glomerular filtration rate, or blood pressure. In WKY but not in SHR, after DNX, the D1 agonist dose-dependently increased UV, UNaV, and FENa in the denervated kidney. We conclude that the decreased natriuretic effect of D1 agonists in the SHR is not due to increased renal nerve activity. These data support our previous studies implicating a defect of the D1 receptor or its regulation in the kidney in genetic hypertension.

References

Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·C J Chen, M F Lokhandwala
Jan 1, 1992·Clinical and Experimental Hypertension. Part A, Theory and Practice·R E Beach
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·D ThomasT O Morgan
Dec 1, 1987·The Journal of Clinical Investigation·E P NordP A Insel
May 1, 1986·Proceedings of the Society for Experimental Biology and Medicine·G F DiBona, L L Sawin
Jun 1, 1981·Acta Physiologica Scandinavica·S E RickstenP Thorén
Aug 1, 1995·Clinical and Experimental Pharmacology & Physiology·M YoshidaS Satoh
Apr 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A AperiaP Greengard
Nov 1, 1993·Japanese Circulation Journal·J KubotaK Kawamura
Apr 1, 1996·American Journal of Hypertension·P A JoseR A Felder

❮ Previous
Next ❯

Citations

Sep 12, 2000·Current Hypertension Reports·P A JoseR A Felder
May 10, 2000·Clinical and Experimental Hypertension : CHE·D P O'Connell, A M Aherne
Dec 5, 1998·Pharmacology & Therapeutics·P A JoseR A Felder
Sep 2, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A Kay, C L Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.