PMID: 3557600Apr 1, 1987Paper

Renal nerves and the pathogenesis of angiotensin-induced hypertension

Hypertension
R C VariR H Freeman

Abstract

The present study examined the role of the renal nerves in the development of hypertension produced by chronic infusion of angiotensin II in the conscious rat. The animals were divided into four groups, and a unilateral nephrectomy was performed. The remaining kidney was denervated in two groups, whereas in the other two groups of animals the nerves were left intact. Four days later either angiotensin II (83 ng/min) or saline infusions were begun through subcutaneously implanted osmotic minipumps. The rats were subsequently studied for 14 days. The results indicate that renal denervation significantly attenuated the pressor response to angiotensin II for approximately 6 days. Following this period, there was no difference in blood pressure between the innervated and denervated rats infused with angiotensin II, as both groups attained a hypertensive level of 170 to 180 mm Hg, which was 60 to 70 mm Hg above the blood pressure of the control rats infused with saline. Kidney norepinephrine content was reduced 95% by the denervation procedure and by 40% following infusion of angiotensin II into rats with intact renal nerves. These data demonstrate that, while the renal nerves appear to play a modulatory role in the development of th...Continue Reading

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Citations

Oct 1, 1994·Biulleten' eksperimental'noĭ biologii i meditsiny·E I Pevtsova, S M Tolpygo
Dec 7, 2006·Current Hypertension Reports·Simon C MalpasCarolyn J Barrett
Aug 2, 1990·European Journal of Pharmacology·R L KlineP F Mercer
Feb 26, 2000·Acta Physiologica Scandinavica·L G NavarJ D Imig
Jan 1, 1997·Clinical and Experimental Pharmacology & Physiology·J L OsbornX R He
Apr 28, 2005·Clinical and Experimental Pharmacology & Physiology·Sarah-Jane GuildSimon C Malpas
Jan 1, 1994·British Journal of Pharmacology·A HilditchM J Robertson
Oct 10, 1997·Journal of Hypertension·D Wang, S Strandgaard
Feb 7, 1998·Hypertension·T E Lohmeier, D A Hildebrandt
Jul 6, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J B GraceliM R Moysés
Jun 1, 1992·Journal of the American College of Nutrition·D E Grobbee
Nov 28, 2013·Current Opinion in Nephrology and Hypertension·Robyn LarsenMarkus Schlaich
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon C Malpas
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger G EvansGeoffrey A Head

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