PMID: 18203916Jan 22, 2008Paper

Renal net acid excretion and plasma leptin are associated with potentially bioactive free glucocorticoids in healthy lean women

The Journal of Nutrition
Thomas RemerChristiane Maser-Gluth

Abstract

Primarily experimental evidence suggests that endogenous glucocorticoids may be suppressed by adipocyte-derived leptin and elevated by dietary acidity. Therefore, we examined whether these factors may also be relevant in healthy adults on unrestricted diets. For this we used a new methodological approach in which potentially bioactive free glucocorticoids were determined as the sum of urinary free cortisol and urinary free cortisone and that also takes into account total adrenal glucocorticoid secretion assessed by the sum of the 3 major urinary glucocorticoid metabolites tetrahydrocortisone, tetrahydrocortisol, and 5alpha-tetrahydrocortisol. Body composition, plasma cortisol, plasma leptin, and 24-h urinary excretion rates of net acid and glucocorticoid metabolites were examined cross-sectionally in 30 healthy adults (15 women; 22-44 y old; BMI 20-25 kg/m2). Plasma leptin, percentage body fat, and body surface area-corrected adrenal glucocorticoid secretion showed the usual sex dimorphism (male vs. female, P < 0.05 in each case: 2.8 +/- 1.6 microg/L vs. 7.6 +/- 4.9 microg/L, 16.8 +/- 4.2% vs. 26.9 +/- 4.9%, and 5.1 +/- 1.6 mg x m(-2) x d(-1) vs. 4.0 +/- 1.3 mg x m(-2) x d(-1), respectively), whereas net acid excretion, plasma ...Continue Reading

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Citations

Jul 3, 2010·Psychosomatic Medicine·Thomas Remer, Lijie Shi
Feb 7, 2014·Critical Reviews in Food Science and Nutrition·Thomas RemerLijie Shi
Nov 8, 2008·Journal of the International Society of Sports Nutrition·John M BerardiA Venket Rao
Apr 1, 2011·The Journal of Clinical Endocrinology and Metabolism·Lijie ShiThomas Remer

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