Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical and genetic features

Virchows Archiv : an International Journal of Pathology
O HesXiming Yang

Abstract

We attempted to investigate the clinicopathological correlation of renal oncocytoma (RO) with renal vein extension. We identified seven ROs with extension into the branches of renal vein. The age of seven patients ranged from 61 to 82 years. Five cases were identified; incidentally, two patients had gross hematuria. After surgery, all patients were alive and free of tumors with follow-up of 1 to 5 years (mean=3.6). Oncocytomas measured from 2.2 to 7.5 cm. Renal vein extension was grossly suspected in 5/7 cases and histologically confirmed in all seven cases. Tumor cells were positive for cytokeratins, mitochondrial antigen, epithelial membrane antigen, and parvalbumin; 5/7 tumors were focally positive for cluster of differentiation 117. Ultrastructurally, the cytoplasm was packed by mitochondria. Molecular genetic analysis did not detect abnormal numbers of chromosomes 1, 2, 6, 7, 10, 17, and XY by fluorescence in situ hybridization, loss of heterozygosity on 3p, and mutation of Von Hippel-Lindau gene in all cases. Array comparative genomic hybridization analysis of two cases did not show any major genetic changes. Conclusions are: (1) renal oncocytomas may have intravascular extension to the branches of the renal vein; (2) ren...Continue Reading

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Citations

Oct 31, 2014·Archives of Pathology & Laboratory Medicine·Oleksandr N KryvenkoJonathan I Epstein
Nov 28, 2015·Surgical Pathology Clinics·Javier A Arias-Stella, Sean R Williamson
May 8, 2016·Current Urology Reports·Jennifer Gordetsky, Jessica Zarzour
Aug 9, 2016·Human Pathology·Sara E WobkerJonathan I Epstein
Jan 12, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sayf Al-KatibSyed Zafar H Jafri
Nov 9, 2019·Therapeutic Advances in Urology·Ayo O Omiyale, James Carton
Sep 6, 2019·Case Reports in Urology·Sumi DeyBrian R Lane
Nov 22, 2019·Medical & Biological Engineering & Computing·Ravinder KaurA K Mandal
Apr 3, 2014·Topics in Magnetic Resonance Imaging : TMRI·Naomi CampbellIvan Pedrosa
Aug 26, 2020·Archives of Medical Research·Maria S Tretiakova

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