PMID: 8945976Nov 1, 1996Paper

Renal organic anion secretion: evidence for dopaminergic and adrenergic regulation

The American Journal of Physiology
P A Halpin, J L Renfro

Abstract

To examine possible regulatory control of renal proximal tubule organic anion secretion, winter flounder (Pleuronectes americanus) proximal tubule primary cultures were mounted in Ussing chambers. Unidirectional fluxes of [2,4-(14)C]dichlorophenoxyacetic acid were determined under short-circuited conditions. Phorbol 12-myristate 13-acetate (1 microM) caused a significant (P < 0.01) inhibition of net 2,4-dichlorophenoxyacetic acid secretion. Preincubation with staurosporine (1 microM) blocked the phorbol 12-myristate 13-acetate-induced decrease in secretion. Neither forskolin (10 microM) nor W-7 (20 microM) had any effect on net transport. Elevation of intracellular calcium activity with either A-23187 or thapsigargin produced a slight, transient decrease in transport. Addition of dopamine (1 microM) to the peritubular side, but not the luminal side, caused a significant (P < 0.01) decrease in net secretion. Both the alpha-adrenergic agonist oxymetazoline (10 microM) and depletion of intracellular Na+ transiently, but significantly (P < 0.05), increased net transport. The data indicate that renal organic anion excretion may be regulated through dopaminergic inhibition and alpha-adrenergic stimulation of net transepithelial secre...Continue Reading

Citations

Dec 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·Shanshan LiGuofeng You
Aug 5, 2000·American Journal of Physiology. Renal Physiology·R A Van AubelF G Russel
Feb 8, 2000·American Journal of Physiology. Renal Physiology·A ShuprishaW H Dantzler
Apr 13, 2004·American Journal of Physiology. Renal Physiology·Klaus W Beyenbach
Jun 3, 2000·American Journal of Physiology. Renal Physiology·G Burckhardt, N A Wolff
Feb 5, 2002·Annual Review of Physiology·Frans G M RusselRemon A M H van Aubel

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