Renal osteodystrophy in children: a systemic disease associated with cardiovascular manifestations

Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society
Craig B Langman, Ellen R Brooks

Abstract

The increasing prevalence of chronic kidney disease (CKD) in the United States demands a closer evaluation of and attention to associated morbidities, and, particularly, the rising mortality related to cardiovascular disease in all age groups. Patients with CKD demonstrate an increased risk of coronary artery disease due to calcium deposition and subsequent arterial stiffening, in addition to left ventricular dysfunction with associated heart failure and arrhythmias. While clearly impacted by the traditional risk factors for development of cardiovascular disease (CVD), patients with CKD are also affected by non-traditional risk factors, including calcium overloading related to aggressive management of secondary hyperparathyroidism. Recent data have shown that a substantial number of patients with CKD are deficient in vitamin D on a nutritional basis, in addition to the known decrease in the kidney-produced active metabolite during progressive CKD. Historically, vitamin D has been described as an endocrine hormone that regulates blood calcium and parathyroid hormone levels. It has become increasingly clear, through the recognition of a vitamin D receptor in most tissues, that vitamin D possesses functions well beyond calcium hom...Continue Reading

References

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Citations

Nov 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees
Jun 26, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Shina MenonTej K Mattoo
Jun 23, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Uwe Querfeld, Robert H Mak
Jun 5, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Basema I Dibas, Bradley A Warady
Apr 11, 2014·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Ji Yeon LeeJennifer Thackray
Jun 24, 2011·Kidney International·Oluwatoyin F Bamgbola
Sep 22, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·J BacchettaP Cochat
Aug 25, 2009·The American Journal of Medicine·Sarah A StechschulteDaniel G Federman
May 27, 2015·Pediatric Transplantation·Kirsten EbbertJanis Dionne
Jan 25, 2017·Bone·Javier A Neyra, Ming Chang Hu
May 13, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohammed Al-BiltagiHesham El-Serogy

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