PMID: 16629221Apr 25, 2006Paper

Renal osteodystrophy: what's in a name? Presentation of a clinically useful new model to interpret bone histologic findings

Clinical Nephrology
H H Malluche, Marie-Claude Monier-Faugere

Abstract

Renal osteodystrophy begins early in the course of chronic kidney disease and occurs almost without exception in all patients with Stage 5 disease (CKD-5). Bone biopsies and evaluation of mineralized bone sections after double tetracycline-labeling are currently considered the gold standard for diagnosis and classification of renal osteodystrophy. Nevertheless, bone biopsies are rarely employed. This is, at least in part, related to the paucity of nephrologists trained in performance of the procedure and the fact that reports of the histologic results are not easily translatable to clinical practice. Results are usually given qualitatively, using non-uniform classifications or by histomorphometric evaluations which are esoteric to most nephrologists. We suggest here that histomorphometric evaluation can be reserved for research and special situations. Also, the customarily used qualitative classification should be replaced by a clinically useful nomenclature, provided the interpretation is done by an individual with sufficient experience in bone pathology. We present a new interactive nomenclature for renal osteodystrophy that addresses abnormalities of turnover, abnormalities of bone balance, and abnormalities of mineralizatio...Continue Reading

Citations

Nov 18, 2009·Nature Reviews. Nephrology·Hartmut H MallucheJohann Herberth
Oct 9, 2013·Nature Reviews. Nephrology·Hartmut H MallucheDavid Pienkowski
Aug 29, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Carol MooreYahya Osman-Malik
Nov 15, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Hartmut H MallucheMarie-Claude Monier-Faugere
Jan 23, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Junichiro James KazamaAkihide Tokumoto
Feb 25, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Inari S TamminenOuti Mäkitie
Oct 16, 2013·Journal of Bone and Mineral Metabolism·Toshio FumotoKyoji Ikeda
Feb 13, 2016·International Urology and Nephrology·Mehmet Nuri TuranErcan Ok
Mar 8, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kamilla Nawrot-WawrzyniakNadja Fratzl-Zelman
Sep 11, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Eric WallaceHeidi Schaefer
Jun 27, 2013·Kidney International·Ranjani N Moorthi, Sharon M Moe
Mar 30, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Johann HerberthHartmut H Malluche
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hartmut H MallucheMarie-Claude Monier-Faugere
Sep 1, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Stuart M SpragueSharon M Moe
Jan 18, 2014·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Mona Al RukhaimiFaissal A M Shaheen
Apr 7, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mathias HaarhausHartmut H Malluche
Jun 21, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Hartmut H MallucheMarie-Claude Monier-Faugere
Sep 10, 2019·Journal of Medical Biochemistry·Mouna BouksilaAfef Bahlous
Oct 11, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H H MallucheD L Davenport
Jun 1, 2020·The Journal of Clinical Endocrinology and Metabolism·Jan M Hughes-AustinJoachim H Ix
May 4, 2017·Current Osteoporosis Reports·Susan M Ott
Oct 10, 2015·The International Journal of Artificial Organs·Gulsum OzkanAdnan Yavuz
Jun 1, 2008·NDT Plus·Vincent M Brandenburg, Jürgen Floege
May 16, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Satu KeronenEero Honkanen
Jan 1, 2020·KI Reports·Daniel W CoyneKeith A Hruska
Feb 16, 2021·Calcified Tissue International·Hanne Skou JørgensenUNKNOWN European Renal Osteodystrophy (EUROD) workgroup, an initiative of the CKD-MBD working group of the ERA-EDTA
Mar 13, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Sonia Sharma, Ankur Gupta

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