Renal Outcomes in Critically Ill Patients Receiving Propofol or Midazolam

Clinical Journal of the American Society of Nephrology : CJASN
Tacyano Tavares LeiteAlexandre Braga Libório

Abstract

Propofol has been shown to provide protection against renal ischemia/reperfusion injury experimentally, but clinical evidence is limited to patients undergoing cardiac surgery. There are no data about its association with oliguria and AKI in critically ill patients. We obtained data from the Multiparameter Intelligent Monitoring in Intensive Care II database (2001-2008). Patient selection criteria included adult patients in their first intensive care unit (ICU) admission, need for mechanical ventilation, and treatment with propofol or midazolam. Propensity score analysis (1:1) was used and renal-related outcomes (AKI, oliguria, cumulative fluid balance, and need for RRT) were evaluated during the first 7 days of ICU stay. There were 1396 propofol/midazolam-matched patients. AKI in the first 7-day ICU time period was statistically lower in propofol-treated patients compared with midazolam-treated patients (55.0% versus 67.3%, P<0.001). Propofol was associated with lower AKI incidence using both urine output (45.0% versus 55.7%, P<0.001) and serum creatinine criteria (28.8% versus 37.2%, P=0.001). Patients receiving propofol had oliguria (<400 ml/d) less frequently (12.4% versus 19.6%, P=0.001) and had diuretics prescribed less o...Continue Reading

References

Jun 1, 1992·British Journal of Anaesthesia·P G MurphyJ G Jones
May 16, 2006·Critical Care : the Official Journal of the Critical Care Forum·Eric A J HosteJohn A Kellum
Jun 29, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·José M Rodríguez-LópezClemente Muriel
Feb 19, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sean M BagshawUNKNOWN ANZICS Database Management Committe
Jun 22, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Etienne MacedoRavindra L Mehta
Sep 25, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chung-Hsi HsingChing-Hua Yeh
May 3, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gilbert R Kinsey, Mark D Okusa
Oct 7, 2011·Kidney International·Kai Singbartl, John A Kellum
Nov 14, 2013·Experimental and Therapeutic Medicine·Shun YangLing Pei
Jan 17, 2014·Kidney International·Young-Chul YooYoung-Lan Kwak
Apr 12, 2014·American Journal of Respiratory and Critical Care Medicine·Nick W LonardoRichard G Barton

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Citations

Dec 17, 2016·Anesthesia and Analgesia·Hong LiuNeal Fleming
Nov 14, 2017·American Journal of Nephrology·Negar MotayagheniAnthony Atala
Dec 1, 2015·Nature Reviews. Nephrology·Etienne Macedo, Ravindra L Mehta
Jan 13, 2018·Current Opinion in Anaesthesiology·Melanie Meersch, Alexander Zarbock
Apr 21, 2019·Drugs·Matthew Hulse, Mitchell H Rosner
Nov 18, 2016·American Journal of Respiratory and Critical Care Medicine·Edward D SiewTimothy D Girard
Mar 30, 2018·Medizinische Klinik, Intensivmedizin und Notfallmedizin·M JoannidisA Zarbock
Aug 11, 2020·Indian Journal of Anaesthesia·Tushar ChokshiLalit Mehdiratta

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