Renal oxygenation changes during acute unilateral ureteral obstruction: assessment with blood oxygen level-dependent mr imaging--initial experience

Radiology
Harriet C ThoenyPeter Vermathen

Abstract

To prospectively determine if changes in intrarenal oxygenation during acute unilateral ureteral obstruction can be depicted with blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging. The study was approved by the local ethics committee, and written informed consent was obtained from all patients. BOLD MR imaging was performed in 10 male patients (mean age, 45 years +/- 17 [standard deviation]; range, 20-73 years) with a distal unilateral ureteral calculus and in 10 healthy age-matched male volunteers to estimate R2*, which is inversely related to tissue Po(2). R2* values were determined in the cortex and medulla of the obstructed and the contralateral nonobstructed kidneys. To reduce external effects on R2*, the R2* ratio between the medulla and cortex was also analyzed. Statistical analysis was performed with nonparametric rank tests. P < .05 was considered to indicate a significant difference. All patients had significantly lower medullary and cortical R2* values in the obstructed kidney (median R2* in medulla, 10.9 sec(-1) [range, 9.1-14.3 sec(-1)]; median R2* in cortex, 10.4 sec(-1) [range, 9.7-11.3 sec(-1)]) than in the nonobstructed kidney (median R2* in medulla, 17.2 sec(-1) [range, 14.6-23.2 sec(-1)], P ...Continue Reading

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Citations

Aug 25, 2011·AJR. American Journal of Roentgenology·Ji Hye MinBohyun Kim
Apr 25, 2012·AJR. American Journal of Roentgenology·Sung Yoon ParkBohyun Kim
Jan 24, 2016·Journal of Magnetic Resonance Imaging : JMRI·Chengyan WangJing Fang
Apr 8, 2011·European Journal of Radiology·Wen-Jie YinRong-Bo Liu
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Jan 24, 2014·American Journal of Physiology. Renal Physiology·Jeff L ZhangVivian S Lee

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