Renal Protective Effect of Hydrogen Sulfide in Cisplatin-Induced Nephrotoxicity

Antioxidants & Redox Signaling
Xu CaoJin-Song Bian

Abstract

Cisplatin is a major therapeutic drug for solid tumors, but can cause severe nephrotoxicity. However, the role and therapeutic potential of hydrogen sulfide (H2S), an endogenous gasotransmitter, in cisplatin-induced nephrotoxicity remain to be defined. Cisplatin led to the impairment of H2S production in vitro and in vivo by downregulating the expression level of cystathionine γ-lyase (CSE), which may contribute to the subsequent renal proximal tubule (RPT) cell death and thereby renal toxicity. H2S donors NaHS and GYY4137, but not AP39, mitigated cisplatin-induced RPT cell death and nephrotoxicity. The mechanisms underlying the protective effect of H2S donors included the suppression of intracellular reactive oxygen species generation and downstream mitogen-activated protein kinases by inhibiting NADPH oxidase activity, which may be possibly through persulfidating the subunit p47phox. Importantly, GYY4137 not only ameliorated cisplatin-caused renal injury but also added on more anticancer effect to cisplatin in cancer cell lines. Innovation and Conclusion: Our study provides a comprehensive understanding of the role and therapeutic potential of H2S in cisplatin-induced nephrotoxicity. Our results indicate that H2S may be a nov...Continue Reading

References

Nov 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F Ries, J Klastersky
Aug 1, 1993·Gynecologic Oncology·T L Cornelison, E Reed
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
May 25, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuka Kimura, Hideo Kimura
Feb 11, 2005·American Journal of Physiology. Renal Physiology·Ganesan Ramesh, W Brian Reeves
Sep 24, 2005·Current Topics in Medicinal Chemistry·Gary L Schieven
Oct 3, 2007·The Journal of Biological Chemistry·Md Ruhul AbidWilliam C Aird
Feb 15, 2008·Kidney International·N Pabla, Z Dong
Jun 24, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Saurabh JhaDavid J Lefer
Jul 29, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Qian Chen YongJin-Song Bian
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Navjotsingh PablaZheng Dong
Feb 21, 2009·The Journal of Physical Chemistry. B·Tomás ZimmermannJaroslav V Burda
Feb 28, 2009·The Journal of Pharmacology and Experimental Therapeutics·Min XiaNingjun Li
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andreas PapapetropoulosCsaba Szabó
Apr 3, 2010·Journal of the American Society of Nephrology : JASN·Ming LuJin-Song Bian
May 7, 2010·Free Radical Biology & Medicine·Ralf P BrandesKatrin Schröder
Sep 8, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Shawn E BeardenJean C Pfau
Nov 1, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohammad A Aminzadeh, Nosratola D Vaziri
Nov 8, 2011·Analytical Biochemistry·Eric R DeLeonKenneth R Olson
Jan 24, 2012·The American Journal of Pathology·Atsushi TakahashiHiromi Rakugi
Mar 2, 2013·Journal of the American Society of Nephrology : JASN·Eelke M BosHarry van Goor
Mar 6, 2013·Free Radical Biology & Medicine·Alyson A MillerBarbara K Kemp-Harper
Nov 29, 2013·Kidney International·Kai SongLi-Fang Hu
Jul 25, 2014·European Journal of Pharmacology·Shaloam Dasari, Paul Bernard Tchounwou
Aug 26, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wen-Jun PanZhi-Sheng Jiang
Sep 18, 2014·ACS Chemical Neuroscience·Xingzhou Zhang, Jin-Song Bian
May 12, 2015·Nitric Oxide : Biology and Chemistry·Kohei IkedaFumito Ichinose
Jun 3, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yimin WangBaiye Jin
Jun 17, 2015·Oxidative Medicine and Cellular Longevity·Guoliang MengYong Ji
Jul 5, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sang Jun HanKwon Moo Park
Jul 15, 2015·Handbook of Experimental Pharmacology·Matthew WhitemanMark E Wood
Dec 8, 2015·Oxidative Medicine and Cellular Longevity·B V Nagpure, Jin-Song Bian

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Citations

Oct 24, 2019·Antioxidants & Redox Signaling·Dawn Sijin NinLih-Wen Deng
Jan 17, 2019·International Journal of Molecular Sciences·Xu CaoJinsong Bian
Apr 18, 2020·Scientific Reports·Eliana PintusJosé Luis Ros-Santaella
Dec 29, 2020·Frontiers in Pharmacology·Ebenezeri Erasto NgowiDong-Dong Wu
Aug 10, 2021·Molecular Medicine Reports·Hu ZhangNannan Guo
Oct 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuan-Zhe JingZhi-Jun Sun
Jan 4, 2022·Antioxidants & Redox Signaling·Maria PeleliAndreas Papapetropoulos

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Methods Mentioned

BETA
protein assay
electrophoresis
PCR

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