Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.

Pharmacological Reports : PR
Ahmed M NasrShimaa M Elshazly

Abstract

Upregulation of the sodium glucose co-transporter (SGLT2) is implicated in acute renal injury (ARI) progression and is regulated by extracellular signal-regulated kinase (ERK), hypoxia-inducible factor 1 alpha (HIF1α) or prostaglandin E2 (PGE2). This study aimed to assess the possible protective effect of nebivolol on renal ischemia/reperfusion (IR) and glycerol-induced ARI targeting SGLT2 via modulating the ERK-HIF1α pathway. Rats were divided into control, sham, IR or nebivolol-treated group, in which rats were treated with nebivolol (10 mg/kg) for 3 days prior to the induction of IR. The rats were subjected to renal ischemia by bilateral clamping of the pedicles for 45 min, followed by 24 h reperfusion. Another group of rats received the vehicle or nebivolol (10 mg/kg) for 3 days followed by injection of 50% glycerol (8 ml/kg, IM) or saline. Kidney function tests, systolic blood pressure (SBP), oxidative stress markers [malondialdehyde (MDA) and NADPH oxidase] and kidney levels of nitric oxide (NO), inducible nitric oxide synthase (iNOS), HIF1α, ERK phosphorylation and PGE2 were determined. Additionally, renal sections were used for histological grading of renal injury and immunological expression of SGLT2. ARI rats showed s...Continue Reading

References

Oct 1, 1984·The Journal of Clinical Investigation·M S PallerT F Ferris
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·L YuR W Schrier
May 15, 1996·The Journal of Clinical Investigation·E NoiriM S Goligorsky
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Feb 1, 1997·Journal of Pharmacological and Toxicological Methods·P WilliamsR Hottendorf
Feb 23, 2000·FEBS Letters·E MinetC Michiels
Sep 12, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Vikas ChanderKanwaljit Chopra
Apr 1, 1964·Proceedings of the Society for Experimental Biology and Medicine·D A SORG, B BUCKNER
Dec 4, 2003·Journal of the American College of Cardiology·Luciano CominaciniVincenzo Lo Cascio
Jul 16, 2004·Kidney International·Faikah GuelerHermann Haller
Feb 1, 2005·European Journal of Pharmacology·Adriana GeorgescuDoina Popov
Mar 24, 2006·American Journal of Physiology. Renal Physiology·Volker H Haase
Jan 25, 2007·American Journal of Physiology. Renal Physiology·Sandra VillanuevaVictoria Velarde
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Alexander WeidemannCarsten Willam
Dec 3, 2008·European Journal of Internal Medicine·Yiannis S ChatzizisisGeorge D Giannoglou
May 16, 2009·Therapeutic Advances in Cardiovascular Disease·Angelo Maffei, Giuseppe Lembo
Jun 6, 2009·Journal of the American Society of Nephrology : JASN·Gilbert R KinseyMark D Okusa
Jul 18, 2009·American Journal of Nephrology·Adam Whaley-ConnellJames R Sowers
Oct 10, 2009·Journal of the American College of Cardiology·Thomas Münzel, Tommaso Gori
May 15, 2012·Pharmacological Reports : PR·Amrit Pal SinghRavi Dhawan
Jul 5, 2012·Journal of Molecular Histology·Mustafa Burak SayhanMustafa Erboga
Sep 21, 2012·American Journal of Physiology. Renal Physiology·Qingqing Wei, Zheng Dong
Nov 13, 2012·Molecular Endocrinology·Annavarapu Hari KishoreR Ann Word
Aug 27, 2013·PloS One·Catherine E EricksonBradley T Andresen
May 30, 2015·Diabetology & Metabolic Syndrome·Nobutaka NakamuraSho-Ichi Yamagishi
Oct 21, 2015·Redox Biology·D Neil Granger, Peter R Kvietys
Oct 30, 2015·Kidney & Blood Pressure Research·Nayara PanizoJuan Antonio Moreno
Dec 1, 2015·Basic & Clinical Pharmacology & Toxicology·Mohamed A Morsy, Gehan H Heeba
Jan 15, 2016·American Journal of Physiology. Renal Physiology·Anita T LaytonAurélie Edwards
May 26, 2016·Journal of Immunotoxicology·Nahla E El-AshmawyHend M Selim
Jul 18, 2016·Advances in Therapy·Sanjay KalraDinesh Nagrale
Dec 19, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rania NasrallahRichard L Hébert

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