Renal protective effects of extracts from guava fruit (Psidium guajava L.) in diabetic mice.

Plant Foods for Human Nutrition
Chia-Yu Lin, Mei-Chin Yin

Abstract

This study analyzed the content of phenolic acids and flavonoids in extracts of guava fruit (Psidium guajava L.), and examined the renal protective effects of guava aqueous extract (GAE) and ethanol extract (GEE) in diabetic mice. GAE had more caffeic acid, myricetin, and quercetin; and GEE had more cinnamic, coumaric and ferulic acids. GAE or GEE at 1 and 2 % was supplied in diet for 12 weeks. GAE or GEE intake at 2 % significantly reduced glucose and blood urea nitrogen levels, increased insulin level in plasma of diabetic mice (p < 0.05). GAE or GEE treatments dose-dependently reserved glutathione content, retained activity of catalase and glutathione peroxidase, and decreased reactive oxygen species, interleukin (IL)-6, tumor necrosis factor-α and IL-1β levels in kidney (p < 0.05). GAE and GEE treatments at 2 % significantly declined renal N (ε)-(carboxymethyl)lysine, pentosidine and fructose levels (p < 0.05), and suppressed renal activity of aldose reductase (p < 0.05). These findings support that guava fruit could protect kidney against diabetic progression via its anti-oxidative, anti-inflammatory and anti-glycative effects.

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Citations

Feb 26, 2016·Chinese Medicine·Jing-Yi LiuKalin Yan-Bo Zhang
Jul 16, 2016·Journal of Traditional and Complementary Medicine·Anand DuraiswamyKotturathu Mammen Cherian
Mar 10, 2017·Redox Report : Communications in Free Radical Research·Noori Al-WailiKhelod Salom
Jul 13, 2017·Clinical and Experimental Pharmacology & Physiology·Mang Hung LinMing Chang Wu
Oct 11, 2017·Pharmacognosy Reviews·Poonam G DaswaniTannaz J Birdi
Apr 18, 2018·Journal of Cellular Physiology·Kiana Hosseinpour-MoghaddamAmirhossein Sahebkar
Jan 1, 2013·ISRN Hepatology·Jian PengHeping Yang
Jan 2, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emad M HassanElsayed A Omer
Jan 10, 2021·Journal of the Science of Food and Agriculture·Jonatan Jafet Uuh-NarvaezMaira Rubí Segura-Campos

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