Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis

Life Sciences
Nehal M ElsherbinyMohamed M Al-Gayyar

Abstract

Sodium nitrite is a widely used color fixative and preservative. However, it has been reported to exert deleterious toxic effects on various body organs. Moreover, thymoquinone (TQ), the active constituent of Nigella sativa oil is known to possess beneficial antioxidant and anti-inflammatory effects. The present study was conducted to evaluate the potential protective effects of TQ against sodium nitrite-induced renal toxicity. Male Sprague-Dawley rats were treated with sodium nitrite (80mg/kg, po, daily) in presence or absence of TQ (25 and 50mg/kg, po, daily). Morphological changes in renal sections were assessed by staining with Hematoxylin/Eosin and Periodic acid-Schiff. Renal homogenate was used for measurement of oxidative stress markers (MDA and GSH), inflammatory markers (CRP, TNF-α, IL-6, IL-1β), anti-inflammatory cytokines (IL-10 and IL-4) and apoptotic markers (caspase-3/caspase-8/caspase-9). Treatment with sodium nitrite significantly increased markers of renal dysfunction, oxidative stress, inflammation and apoptosis. These effects were markedly attenuated by TQ in dose dependent manner. TQ has a potential protective effect against sodium nitrite-induced renal toxicity. This can be attributed to its ability to damp...Continue Reading

Citations

Oct 29, 2018·Journal of Cellular Biochemistry·Fariheen Aisha AnsariRiaz Mahmood
Dec 15, 2017·Journal of Cellular Biochemistry·Fariheen Aisha AnsariRiaz Mahmood
Apr 18, 2018·Dose-response : a Publication of International Hormesis Society·Tahereh FarkhondehFariborz Samini
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yun NiuWenyi Kang
Sep 15, 2020·Dose-response : a Publication of International Hormesis Society·Aliah R AlshanwaniAlaa AlHarthii
Nov 6, 2020·Environmental Science and Pollution Research International·Mai M EissaSahar H Orabi
May 1, 2021·Pharmaceuticals·Belal AlmajaliWisam Nabeel Ibrahim

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