Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension

Hypertension
Alvaro YogiRhian M Touyz

Abstract

We demonstrated previously that, in mice with chronic angiotensin II-dependent hypertension, gp91phox-containing NADPH oxidase is not involved in the development of high blood pressure, despite being important in redox signaling. Here we sought to determine whether a gp91phox homologue, Nox1, may be important in blood pressure elevation and activation of redox-sensitive pathways in a model in which the renin-angiotensin system is chronically upregulated. Nox1-deficient mice and transgenic mice expressing human renin (TTRhRen) were crossed, and 4 genotypes were generated: control, TTRhRen, Nox1-deficient, and TTRhRen Nox1-deficient. Blood pressure and oxidative stress (systemic and renal) were increased in TTRhRen mice (P<0.05). This was associated with increased NADPH oxidase activation. Nox1 deficiency had no effect on the development of hypertension in TTRhRen mice. Phosphorylation of c-Src, mitogen-activated protein kinases, and focal adhesion kinase was significantly increased 2- to 3-fold in kidneys from TTRhRen mice. Activation of c-Src, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and focal adhesion kinase but not of extracellular signal regulated kinase 1/2 or extracellular signal regulated kinase 5, w...Continue Reading

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Citations

Apr 29, 2010·Current Hypertension Reports·Ana M Briones, Rhian M Touyz
Jun 2, 2011·Nature Reviews. Drug Discovery·Grant R DrummondChristopher G Sobey
May 12, 2009·Current Opinion in Nephrology and Hypertension·Mona SedeekRhian M Touyz
Jul 20, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Anna E DikalovaKathy K Griendling
Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Bernard Lassègue, Kathy K Griendling
May 15, 2012·Circulation Research·Bernard LassègueKathy K Griendling
Jul 21, 2010·Hypertension·Srinivasa Raju Datla, Kathy K Griendling
Jan 17, 2012·Journal of Clinical Biochemistry and Nutrition·Masato KatsuyamaChihiro Yabe-Nishimura
May 27, 2010·Redox Report : Communications in Free Radical Research·Jennifer RiveraGrant R Drummond
Apr 23, 2013·Antioxidants & Redox Signaling·Augusto C Montezano, Rhian M Touyz
Mar 29, 2014·Journal of Hypertension·Elsa C ChanFan Jiang
Nov 5, 2013·Antioxidants & Redox Signaling·Anna KoniorTomasz J Guzik
Apr 2, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stephen P Gray, Karin Jandeleit-Dahm
Jun 20, 2012·Journal of Cardiovascular Translational Research·Mona SedeekRhian M Touyz
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May 20, 2008·Seminars in Immunopathology·Tomoko Kakehi, Chihiro Yabe-Nishimura
Nov 8, 2014·Expert Opinion on Emerging Drugs·Giorgio GentileGiuseppe Remuzzi
Jun 22, 2012·Annals of Medicine·Augusto C Montezano, Rhian M Touyz
Feb 11, 2016·Trends in Pharmacological Sciences·Gábor SirokmányMiklós Geiszt
Mar 23, 2011·Journal of the American Society of Hypertension : JASH·Ana M BrionesRhian M Touyz
Dec 9, 2008·Molecular and Cellular Endocrinology·Abel Martin Garrido, Kathy K Griendling
Sep 23, 2008·Pharmacology & Therapeutics·Stavros SelemidisGrant R Drummond
Sep 2, 2010·International Journal of Experimental Pathology·Amélie DendoovenJaap A Joles
Feb 26, 2016·Antioxidants & Redox Signaling·Jay C JhaKarin A Jandeleit-Dahm
Jan 5, 2014·Antioxidants & Redox Signaling·Sebastian AltenhöferHarald H H W Schmidt
Feb 6, 2013·Clinical Science·Jennifer L Wilkinson-BerkaAlex Agrotis
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Jan 28, 2015·The American Journal of Pathology·Danielle L ZimmermanKevin D Burns
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Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
May 19, 2010·Hypertension·Ralf P Brandes
Oct 20, 2018·Antioxidants & Redox Signaling·Rhian M TouyzAugusto C Montezano
Dec 19, 2015·Clinical Science·Marcela GimenezFrancis J Miller
Aug 26, 2017·Journal of Receptor and Signal Transduction Research·Rashidul HaqueBhavna Kumar
Mar 18, 2011·American Journal of Physiology. Renal Physiology·Nicolas ClavreulAlain Rupin
Mar 1, 2014·Expert Review of Endocrinology & Metabolism·Stephen P GrayKarin Am Jandeleit-Dahm

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