Renal Remission Status and Longterm Renal Survival in Patients with Lupus Nephritis: A Retrospective Cohort Analysis

The Journal of Rheumatology
Julie E DavidsonMichelle Petri

Abstract

This observational study was a retrospective analysis of prospectively collected Hopkins Lupus Cohort data to compare longterm renal survival in patients with lupus nephritis (LN) who achieved complete (CR), partial (PR), or no remission following standard-of-care LN induction therapy. Eligible patients with biopsy-proven LN (revised American College of Rheumatology or Systemic Lupus Collaborating Clinics criteria) were identified and categorized into ordinal (CR, PR, or no remission) or binary (response or no response) renal remission categories at 24 months post-diagnosis [modified Aspreva Lupus Management Study (mALMS) and modified Belimumab International Lupus Nephritis Study (mBLISS-LN) criteria]. The primary endpoint was longterm renal survival [without endstage renal disease (ESRD) or death]. In total, 176 patients met the inclusion criteria. At Month 24 postbiopsy, more patients met mALMS remission criteria (CR = 59.1%, PR = 30.1%) than mBLISS-LN criteria (CR = 40.9%, PR = 16.5%). During subsequent followup, 18 patients developed ESRD or died. Kaplan-Meier plots suggested patients with no remission at Month 24 were more likely than those with PR or CR to develop the outcome using either mALMS (p = 0.0038) and mBLISS-LN ...Continue Reading

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Citations

Sep 17, 2020·The New England Journal of Medicine·Richard FurieDavid A Roth
Jun 6, 2020·Current Rheumatology Reports·Myrto KostopoulouGeorge Bertsias
Jun 7, 2020·Annals of the Rheumatic Diseases·Gabriella MoroniAndrea Doria
Jul 30, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise OniKjell Tullus
Dec 7, 2020·Rheumatology·Michela GasparottoGabriella Moroni
Aug 12, 2021·Indian Journal of Nephrology·M LimeshN Vinod

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