Renal response of the lamb fetus to partial occlusion of the umbilical cord.

The Journal of Pediatrics
S S DanielL S James

Abstract

The role of the fetal kidney during impairment of placental exchange was studied in eight fetal lambs, intact in utero; a standard asphyxial insult for a period of 1 hour was produced by occluding the umbilical cord sufficiently to lower the fetal heart rate by 35 +/- 5 beats/min and the pH by 0.15 units. This asphyxial stress caused a fall in urine output from a control of 0.17 to 0.03 ml/kg/min and of glomerular filtration rate from 1.2 to 0.3 ml/min; release of the occlusion was followed by mild diuresis. The fall in urine output was accompanied by a rise in total primary solutes including concentrations of electrolytes; this rise continued for 1 to 2 hours following the release of the occlusion. Because of the low urinary output during the period of occlusion, there was a fall in excretion of electrolyte; an increase in net acid excretion occurred only after the release of the cord. These experiments show that, although the fetal kidney is capable of contributing to elimination of acid following compression of the cord, there may be an associated net loss of water and electrolytes.

References

Jan 1, 1972·Biology of the Neonate·D P AlexanderD Tunbridge
Jan 1, 1972·Biology of the Neonate·A I HymanL S James
Aug 1, 1967·Circulation Research·A G CampbellA I Hyman
Nov 15, 1970·American Journal of Obstetrics and Gynecology·R E BehrmanA E Seeds
Jan 1, 1972·The Journal of Clinical Investigation·E L GreshamF C Battaglia
Jun 1, 1972·Pediatric Research·S S DanielL S James
Nov 22, 1966·Annals of the New York Academy of Sciences·L E Earley
Jan 1, 1970·American Journal of Obstetrics and Gynecology·F G Smith, A Schwartz
Nov 1, 1967·Pediatric Research·C M EdelmannH Stark
Jan 1, 1957·Scandinavian Journal of Clinical and Laboratory Investigation·K JORGENSEN
Jan 1, 1960·Scandinavian Journal of Clinical and Laboratory Investigation·O S ANDERSENP ASTRUP
Apr 1, 1961·Proceedings of the Society for Experimental Biology and Medicine·K THURAU
Jul 1, 1965·The Journal of Clinical Investigation·J H DIRKSR W BERLINER
Jul 1, 1949·The Journal of Clinical Investigation·E Y BergerM Pruss
Dec 1, 1946·The American Journal of Physiology·J C STICKNEYE J VAN LIERE
Jan 1, 1946·The American Journal of Physiology·R A PHILLIPS, V P DOLE

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Citations

May 1, 1981·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J L EversC B Martin
Aug 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P ArbeilleM Deufel
Oct 1, 1991·American Journal of Obstetrics and Gynecology·L J GroomeJ C Hauth
Jun 1, 1984·Early Human Development·B S StonestreetW Oh
Mar 17, 1999·American Journal of Obstetrics and Gynecology·S S DanielL S James
Nov 1, 1994·Journal of Pediatric Surgery·F KizilcanA Hiçsönmez
Jan 1, 1981·Circulation Research·J E RobillardF G Smith
Jan 1, 1996·Clinical and Experimental Pharmacology & Physiology·M L CockR Harding
Mar 1, 1986·The American Journal of Physiology·M G ErvinD A Fisher

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