Renal response to L-arginine in salt-sensitive patients with essential hypertension

Hypertension
Y HigashiG Kajiyama

Abstract

This study examined whether disturbances in nitric oxide formation contribute to renal dysfunction in salt-sensitive essential hypertensive patients. We evaluated the effects of intravenous administration of L-arginine (500 mg/kg given over 30 minutes) on systemic and renal hemodynamics in 23 patients with mild essential hypertension during 1 week of a low NaCl diet (50 mmol/d) followed by 1 week of a high NaCl diet (340 mmol/d). Patients were classified as salt sensitive (n=10) or salt resistant (n=13) based on salt-induced changes in their blood pressures. Salt loading increased renal vascular resistance but not renal plasma flow in salt-sensitive patients. The L-arginine-induced renovascular relaxation was significantly reduced by a high NaCl diet (renal vascular resistance: low NaCl -12.4 +/- 2.3% versus high NaCl -7.1 +/- 1.8%, P < .001) in salt-sensitive patients, whereas it was unchanged in salt-resistant patients. The increase in plasma cGMP in response to L-arginine was also reduced by a high NaCl diet in the salt-sensitive patients (low NaCl 49 +/- 7% versus high NaCl 36 +/- 8%, P < .05) but not in the salt-resistant patients (low NaCl 51 +/- 6% versus high NaCl 58 +/- 6%). These findings suggest that NaCl loading in ...Continue Reading

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Citations

Mar 2, 2002·Journal of Diabetes and Its Complications·Yukihito Higashi, Kazuaki Chayama
Jun 17, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Joanna DziwuraKrystyna Widecka
Apr 6, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kenichi GotoTakanari Kitazono
Jan 27, 1998·Current Opinion in Nephrology and Hypertension·A J Maxwell, J P Cooke
Oct 26, 2012·Current Opinion in Nephrology and Hypertension·Niwanthi W Rajapakse, David L Mattson
Jan 30, 2009·The Journal of Nutrition·Juan LiXiang-An Li
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hans OberleithnerMartin Hausberg
Jul 8, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S A GouvêaG R Abreu
Dec 27, 2017·Current Opinion in Nephrology and Hypertension·Theodore W KurtzR Curtis Morris
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Aug 13, 2020·Biomedicines·Jessica GambardellaValentina Trimarco
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Apr 3, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Theodore W KurtzR Curtis Morris
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