PMID: 9557932Apr 29, 1998Paper

Renal response to the angiotensin II receptor subtype 1 antagonist irbesartan versus enalapril in hypertensive patients

Journal of Hypertension
A Pechère-BertschiM Burnier

Abstract

To compare the acute and sustained renal hemodynamic effects on hypertensive patients of 100 mg irbesartan and 20 mg enalapril each once daily. Twenty patients (aged 35-70 years) with uncomplicated, mild-to-moderate essential hypertension and normal serum creatinine levels completed this study. After random allocation to treatment (n=10 per group), administration schedule (morning or evening) was determined by further random allocation, with crossover of schedules after 6 weeks' therapy. Treatment and administration assignments were double-blind. Twenty-four-hour ambulatory blood pressure was monitored before and after 6 and 12 weeks of therapy. Renal hemodynamics were determined on the first day of drug administration and 12 and 24 h after the last dose during chronic treatment. Administration of each antihypertensive agent induced a renal vasodilatation with no significant change in glomerular filtration rate. However, the time course appeared to differ: irbesartan had no significant acute effect 4 h after the first dose, but during chronic administration a renal vasodilatory response was found 12 and 24 h after the dose; enalapril was effective acutely and 12 h after administration, but no residual effect was found 24 h afte...Continue Reading

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Citations

Mar 4, 2000·Lancet·M Burnier, H R Brunner
May 3, 2000·Kidney International·M W Taal, B M Brenner
Feb 19, 2002·Kidney International·Antoinette Pechère-BertschiMichel Burnier
Sep 13, 2003·Kidney International·Antoinette Pechère-BertschiMichel Burnier
Jul 27, 1999·Journal of Hypertension·W H Birkenhäger, P W de Leeuw
Mar 15, 2001·Blood Pressure Monitoring·J M Neutel
Sep 30, 2008·International Journal of Clinical Practice·L-L ZhuS Zeng
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Georgios K PaschosGarret A FitzGerald
Sep 29, 2011·Integrated Blood Pressure Control·Valentina ForniMichel Burnier
Oct 15, 2013·Vascular Health and Risk Management·Fotini Gialama, Nikos Maniadakis
Jan 6, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Christopher Hassler, Michel Burnier
Oct 20, 2012·Chronobiology International·Ramón C HermidaFrancesco Portaluppi
Dec 15, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ramón C HermidaFrancesco Portaluppi
Apr 20, 2016·Pharmaceutics·Gagandeep KaurBandana Saini
Aug 16, 2016·Frontiers in Physiology·Holly Digne-MalcolmKeith L Dorrington
Dec 18, 2014·The Annals of Pharmacotherapy·Paul M StrangesAmie D Brooks
Apr 24, 2013·Nature Reviews. Nephrology·Ramón C HermidaFrancesco Portaluppi
Feb 15, 2001·Circulation·M Burnier
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Bernard Waeber, Michel Burnier
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·A MimranG DuCailar
Oct 7, 2011·The Cochrane Database of Systematic Reviews·Ping ZhaoZhengrong Wang
Jul 17, 2008·Drugs·Katherine F Croom, Greg L Plosker
Feb 7, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K Melissa HallowAnna Georgieva Kondic

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