PMID: 9179460Mar 1, 1997Paper

Renal response to volume expansion in streptozotocin-induced diabetic rats: influence of calcium channel blockade

Diabetes Research and Clinical Practice
Kaushik P PatelM L Kauker

Abstract

The renal response to volume expansion (VE) has been shown to be impaired in streptozotocin (STZ)-induced diabetes. This may contribute to the abnormal maintenance of fluid balance in diabetics. Since calcium channel blockade (CaCb) has been shown to improve renal hemodynamic and tubular functions, the present studies were designed to examine the ability of CaCb to enhance the response of kidneys from diabetic rats to a volume load. Rats were made diabetic by a single injection of STZ (65 mg i.p.), while the control rats received only a vehicle injection. Nisoldipine, a CaCb agent was given to half of the diabetic rats in a dose of 0.015 microgram/kg per min during the acute experiment. The left kidney was denervated in each rat while the right kidney remained innervated. Glomerular filtration rate (GFR) was elevated during VE in all of the rats except in the denervated kidneys of diabetic rats. Nisoldipine improved GFR in most cases. Urine flow increased markedly during VE. This response was enhanced by denervation but depressed in the diabetic rats. Nisoldipine improved the defective volume reflex in primarily the denervated kidneys. Changes in net urinary excretion of water and sodium during VE were significantly lower in th...Continue Reading

References

Jan 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·M L Kauker
Jan 1, 1987·Journal of Cardiovascular Pharmacology·G GiebischM T Klein-Robbenhaar
Jan 1, 1987·Journal of Cardiovascular Pharmacology·M L KaukerE T Zawada
Jan 1, 1987·Journal of Cardiovascular Pharmacology·M SteinhausenN Parekh
Jan 1, 1995·Diabetes Research and Clinical Practice·K P Patel, P L Zhang

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Citations

May 2, 2003·British Journal of Pharmacology·Orawan Wongmekiat, Edward J Johns

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