Renal safety of intravenous gadolinium-enhanced magnetic resonance imaging in patients awaiting liver transplantation

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Katherine M ShafferRam M Subramanian

Abstract

Renal dysfunction in cirrhosis carries a high morbidity and mortality. Given the potential risk of contrast-induced nephropathy associated with iodinated intravenous contrast used in computed tomography (CT), alternate contrast modalities for abdominal imaging in liver transplant candidates need to be examined. The purpose of this study was to examine the renal safety of magnetic resonance imaging (MRI) with gadolinium in patients awaiting liver transplantation. The study involved a retrospective analysis of 352 patients of abdominal MRI with low-dose gadobenate dimeglumine (MultiHance) (0.05 mmol/kg) in patients with cirrhosis and without renal replacement therapy at a single center during the period from 2007 to 2013. For each case, serum creatinine before and within a few days after the MRI were compared. In addition, the patients were analyzed for the development of nephrogenic systemic fibrosis (NSF), a reported complication of gadolinium in chronic kidney disease. The pre-MRI serum creatinine values ranged from 0.36 to 4.86 mg/dL, with 70 patients (20%) having values ≥ 1.5 mg/dL. A comparison of the pre- and post-MRI serum creatinine values did not demonstrate a clinically significant difference (mean change = 0.017 mg/dL...Continue Reading

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Citations

Apr 28, 2018·Abdominal Radiology·Raj GondaliaMustafa R Bashir
May 1, 2018·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Nicola SchiedaSwapnil Hiremath
Nov 13, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Po-Hsun HuangYu-Fan Cheng
Jun 23, 2020·Annals of Internal Medicine·Joseph LunyeraKaren M Goldstein

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