PMID: 8967399Apr 1, 1996Paper

Renal sensory receptor activation causes prostaglandin-dependent release of substance P

The American Journal of Physiology
U C KoppL A Smith

Abstract

Renal mechanoreceptor (MR) activation by increased ureteral pressure (increases UP) results in an increase in afferent renal nerve activity (ARNA) that is blocked by substance P receptor blockade and prostaglandin (PG) synthesis inhibition. To examine the interaction between substance P and PGs, the release of substance P and PGE into the renal pelvis was studied before and during renal pelvic perfusion with indomethacin. Before indomethacin, increases UP increased ARNA 43 +/- 6% and renal pelvic release of substance P from 11 +/- 3 to 29 +/- 8 pg/min and PGE from 319 +/- 71 to 880 +/- 146 pg/min. Indomethacin blocked the increases in ARNA and release of substance P and PGE produced by increases UP. Time control experiments showed reproducible increases in ARNA and release of substance P and PGE during increases UP. Mechanical stimulation of the renal pelvic wall in vitro resulted in an increase in PGE release from 110 +/- 8 to 722 +/- 152 pg/min, which was abolished by indomethacin, suggesting a de novo PGE synthesis. The data suggest that increases UP results in a renal pelvic release of PGE, which facilitates the release of substance P and activation of renal pelvic MR.

Citations

Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·U C KoppT Hökfelt
Dec 18, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C KoppLori A Smith
May 15, 2003·American Journal of Physiology. Renal Physiology·Ulla C KoppLori A Smith
Oct 7, 2006·The Journal of Physiology·Brett J Wong, Christopher T Minson
Mar 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·John Ciriello
Nov 21, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C Kopp
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·U C KoppL A Smith
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C KoppLori A Smith
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla C KoppLori A Smith

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