Renal sodium and magnesium reabsorption are not coupled in a mouse model of Gordon syndrome.

Physiological Reports
Wouter H van MegenJenny van der Wijst

Abstract

Active reabsorption of magnesium (Mg2+ ) in the distal convoluted tubule (DCT) of the kidney is crucial for maintaining Mg2+ homeostasis. Impaired activity of the Na+ -Cl- -cotransporter (NCC) has been associated with hypermagnesiuria and hypomagnesemia, while increased activity of NCC, as observed in patients with Gordon syndrome, is not associated with alterations in Mg2+ balance. To further elucidate the possible interrelationship between NCC activity and renal Mg2+ handling, plasma Mg2+ levels and urinary excretion of sodium (Na+ ) and Mg2+ were measured in a mouse model of Gordon syndrome. In this model, DCT1-specific expression of a constitutively active mutant form of the NCC-phosphorylating kinase, SPAK (CA-SPAK), increases NCC activity and hydrochlorothiazide (HCTZ)-sensitive Na+ reabsorption. These mice were normomagnesemic and HCTZ administration comparably reduced plasma Mg2+ levels in CA-SPAK mice and control littermates. As inferred by the initial response to HCTZ, CA-SPAK mice exhibited greater NCC-dependent Na+ reabsorption together with decreased Mg2+ reabsorption, compared to controls. Following prolonged HCTZ administration (4 days), CA-SPAK mice exhibited higher urinary Mg2+ excretion, while urinary Na+ excr...Continue Reading

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Citations

Feb 7, 2019·Pflügers Archiv : European journal of physiology·Manuel Meurer, Klaus Höcherl
Aug 1, 2019·American Journal of Physiology. Renal Physiology·Mohammed Z FerdausJames A McCormick
May 14, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Periklis KatopodisKonstantinos P Katopodis
Nov 3, 2020·American Journal of Physiology. Renal Physiology·Yujiro Maeoka, James A McCormick
Jul 1, 2020·Acta Physiologica·Gijs A C FrankenJeroen H F de Baaij

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