Renal sodium handling in experimental diabetes: role of NO

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
R Komers, M E Cooper

Abstract

Recent studies have suggested that diabetes is a state of increased renal nitric oxide (NO) activity as assessed by urinary excretion of nitrites and nitrates (NOx), and that NO synthase inhibitors reverse the increased glomerular filtration rate (GFR) observed in experimental diabetes. In addition to being a potent vasodilator in the renal vasculature, NO also plays a role in modulation of renal sodium excretion. To explore the role of NO in diabetes-associated alterations in renal excretory function, renal haemodynamic and sodium handling parameters were evaluated in conscious control (C) and streptozotocin diabetic rats (D) and correlated to the renal activity of NO, as assessed by urinary excretion of its metabolites NOx. To further explore this issue, the changes in renal haemodynamics and sodium handling were also assessed after NO synthase inhibition with a non-pressor dose of L-nitro-arginine-methyl-ester (L-NAME) and after administration of the NO donor, glyceryl trinitrate (GTN). Systolic blood pressure was not different between C and D rats. D rats exhibited marked hyperglycaemia (P < 0.001), and increases in GFR (P < 0.001), renal plasma flow, filtration fraction, urinary sodium excretion (UNaV, P < 0.001), filtered...Continue Reading

Citations

Aug 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·R SimkováT Pelikánová
Dec 29, 2004·Autonomic Neuroscience : Basic & Clinical·Beatriz D'Agord SchaanUbiratan Fabres Machado
Apr 15, 2014·Free Radical Biology & Medicine·Eduardo Molina-JijónJosé L Reyes
Feb 24, 2015·The Journal of Nutritional Biochemistry·Eduardo Molina-JijónJosé L Reyes
Jul 29, 2005·The American Journal of Pathology·Tadeusz PawelczykAndrzej Szutowicz
May 30, 2017·Asian Pacific Journal of Tropical Medicine·Samah A El-NewaryE A Omer
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·Y DingD D Roh

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