Renal stem cells: fact or science fiction?

The Biochemical Journal
Kristen K McCampbell, Rebecca A Wingert

Abstract

The kidney is widely regarded as an organ without regenerative abilities. However, in recent years this dogma has been challenged on the basis of observations of kidney recovery following acute injury, and the identification of renal populations that demonstrate stem cell characteristics in various species. It is currently speculated that the human kidney can regenerate in some contexts, but the mechanisms of renal regeneration remain poorly understood. Numerous controversies surround the potency, behaviour and origins of the cell types that are proposed to perform kidney regeneration. The present review explores the current understanding of renal stem cells and kidney regeneration events, and examines the future challenges in using these insights to create new clinical treatments for kidney disease.

References

Jun 1, 1977·Biulleten' eksperimental'noĭ biologii i meditsiny·V I Fedorov, Iu L Perov
Feb 1, 1992·The Anatomical Record·J R Nyengaard, T F Bendtsen
Jan 1, 1992·Kidney International·I W GibsonG B Lindop
Jan 1, 1992·Kidney International·F G Toback
Nov 1, 1990·Kidney International·A S WoolfL G Fine
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L Saxén, H Sariola
Jun 1, 1987·Toxicology Letters·G M Ledda-ColumbanoP Pani
Jan 1, 1987·Acta Physiologica Scandinavica·K SahlinH Sjöholm
Jan 1, 1981·Virchows Archiv. A, Pathological Anatomy and Histology·J AlroyA W Miller
Jun 1, 1994·Journal of the American Society of Nephrology : JASN·T NadasdyF G Silva
May 30, 1996·The New England Journal of Medicine·R ThadhaniJ V Bonventre
Jul 9, 1998·The New England Journal of Medicine·P FiorettoM Mauer
Sep 9, 1998·The American Journal of Physiology·A ZukK S Matlin
Oct 3, 2001·ILAR Journal·R Reimschuessel
Feb 19, 2002·Kidney International·Qais Al-Awqati, Juan A Oliver
Mar 13, 2003·American Journal of Physiology. Renal Physiology·Stefanie U VogelmannKevin V Lemley
May 20, 2003·Kidney International·Michael HughsonJohn F Bertram
May 23, 2003·Journal of the American Society of Nephrology : JASN·Joseph V Bonventre
May 23, 2003·Journal of the American Society of Nephrology : JASN·Marlies ElgerHermann Haller
May 31, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dinyar B Bhathena
Oct 1, 1958·Experimental Cell Research·R AUERBACH, C GROBSTEIN
Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Akito MaeshimaYoshihisa Nojima
Dec 25, 2003·Journal of the American Society of Nephrology : JASN·Marcus J MoellerLawrence B Holzman
Feb 10, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·M L GrossK Amann
Sep 17, 2004·The Journal of Clinical Investigation·Juan A OliverQais Al-Awqati
Dec 22, 2004·Kidney International·Arndt T PetermannStuart J Shankland
Jan 25, 2005·Lancet·A Meguid El Nahas, Aminu K Bello
Feb 1, 2005·The American Journal of Pathology·Benedetta BussolatiGiovanni Camussi
Jun 22, 2005·The Journal of Cell Biology·Keiichi HishikawaToshiro Fujita
Jul 12, 2005·The Journal of Clinical Investigation·Fangming LinPeter Igarashi
Jul 23, 2005·The EMBO Journal·Harald Mikkers, Jonas Frisén
Aug 17, 2005·Nature Reviews. Molecular Cell Biology·Craig E EckfeldtCatherine M Verfaillie
Sep 1, 2005·Histochemistry and Cell Biology·Alexander VogetsederMichel Le Hir
Nov 2, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shinji KitamuraHirofumi Makino

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Citations

May 22, 2013·Clinical and Translational Medicine·Yue Li, Rebecca A Wingert
Jan 7, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Francesca BecherucciPaola Romagnani
Nov 14, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Paul J D Winyard, Karen L Price
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Katja BergerMarcus Johannes Moeller
Jan 17, 2014·Histochemistry and Cell Biology·Will W Minuth, Lucia Denk
Nov 5, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Kristen K McCampbell, Rebecca A Wingert
Jun 13, 2014·Genesis : the Journal of Genetics and Development·Paul T Kroeger, Rebecca A Wingert
Jul 5, 2016·Materials·Robert A McKee, Rebecca A Wingert
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Koji Takaori, Motoko Yanagita
Sep 14, 2014·Seminars in Nephrology·Katja Berger, Marcus J Moeller
Feb 11, 2015·The Journal of Pathology·Tomomi EndoMotoko Yanagita
Dec 3, 2014·Gene Expression Patterns : GEP·Robert McKeeRebecca A Wingert
Jun 10, 2015·ELife·Hanh Thi-Kim VuAlejandro Sánchez Alvarado
Jun 20, 2015·Stem Cells International·Kristen K McCampbellRebecca A Wingert
Dec 10, 2015·PloS One·Jianwen WangTom F Lue
Jul 9, 2016·Genesis : the Journal of Genetics and Development·Amanda N MarraRebecca A Wingert
Sep 27, 2014·World Journal of Stem Cells·Elvin E Morales, Rebecca A Wingert
Mar 17, 2016·World Journal of Stem Cells·Bridgette E Drummond, Rebecca A Wingert
Feb 28, 2019·NMR in Biomedicine·Glen Robert MorrellVivian Shu-Ching Lee
Nov 8, 2013·American Journal of Physiology. Renal Physiology·Marcela Herrera, Maria Mirotsou
May 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aneta Ostróżka-Cieślik, Barbara Dolińska
Dec 19, 2019·International Journal of Molecular Sciences·Nadezda V AndrianovaDmitry B Zorov
Jan 1, 2016·AIMS Bioengineering·Joseph M ChambersRebecca A Wingert
Oct 8, 2020·Cells·Joseph M Chambers, Rebecca A Wingert

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Methods Mentioned

BETA
transgenic
biopsies

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