Renal structural changes in insulin-dependent diabetic patients with albuminuria. Comparison of cases with onset of albuminuria after short or long duration

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
R OsterbyJ Asplund

Abstract

The large interindividual variation in diabetes duration until the onset of nephropathy is partly unexplained. This study was performed to compare renal structure in insulin-dependent (IDDM) patients who had developed signs of nephropathy after a short or long duration of diabetes. Renal biopsies were obtained from 17 IDDM patients, with albumin excretion rate 20-300 microg/min and normal blood pressure. Six patients had <25 years duration ("short-term", early onset of microalbuminuria) and eight patients had duration >30 years ("long-term", late onset of microalbuminuria). Biopsies were obtained 18 months after entry into a study testing the effect of low-dose antihypertensives. Parameters characterizing diabetic glomerulopathy were significantly increased in IDDM patients compared with those in 17 living donors: Basement membrane thickness, mean and (CV): 591 nm (0.17) vs 320 nm (0.12), mesangial volume fraction per glomerulus 0.27 (0.19) vs 0.19 (0.10), matrix volume fraction per glomerulus 0.16 (0.20) vs 0.097 (0.22), matrix star volume 38.5 microm3 (0.43) vs 13.9 microm3 (0.31), (p<10(-4) for each). Comparison of short vs long-term patients showed no significant differences in glomerulopathy parameters, glomerular volume o...Continue Reading

References

Oct 31, 1992·BMJ : British Medical Journal·C M ForsblomL C Groop
Feb 1, 1992·The Anatomical Record·J R Nyengaard, T F Bendtsen
Mar 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·C K Christensen, C E Mogensen
May 1, 1987·Diabetic Medicine : a Journal of the British Diabetic Association·K Borch-JohnsenJ Nerup
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Nov 1, 1985·Diabetes Care·G NybergG Nordén
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
May 1, 1982·Kidney International·K HiroseH J Gundersen
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·B Kappel, S Olsen
Mar 1, 1993·Kidney International·P H LaneS M Mauer

❮ Previous
Next ❯

Citations

Sep 17, 2011·American Journal of Physiology. Renal Physiology·Alex Yuri Simões SatoAlexandre Holthausen Campos
Mar 12, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Edward C CarlsonPaul N Epstein
Apr 30, 2002·Diabetes·Keith DrummondUNKNOWN International Diabetic Nephropathy Study Group
Apr 6, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tarnjit KheraAled O Phillips
Nov 7, 2002·American Journal of Physiology. Renal Physiology·Barinder P S KangLeonard G Meggs
May 31, 2001·Kidney International·M W SteffesUNKNOWN International Diabetic Nephropathy Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.