Renal sympathetic nerve activity during asphyxia in fetal sheep

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Lindsea C BoothLaura Bennet

Abstract

The sympathetic nervous system (SNS) is an important mediator of fetal adaptation to life-threatening in utero challenges, such as asphyxia. Although the SNS is active well before term, SNS responses mature significantly over the last third of gestation, and its functional contribution to adaptation to asphyxia over this critical period of life remains unclear. Therefore, we examined the hypotheses that increased renal sympathetic nerve activity (RSNA) is the primary mediator of decreased renal vascular conductance (RVC) during complete umbilical cord occlusion in preterm fetal sheep (101 ± 1 days; term 147 days) and that near-term fetuses (119 ± 0 days) would have a more rapid initial vasomotor response, with a greater increase in RSNA. Causality of the relationship of RSNA and RVC was investigated using surgical (preterm) and chemical (near-term) denervation. All fetal sheep showed a significant increase in RSNA with occlusion, which was more sustained but not significantly greater near-term. The initial fall in RVC was more rapid in near-term than preterm fetal sheep and preceded the large increase in RSNA. These data suggest that although RSNA can increase as early as 0.7 gestation, it is not the primary determinant of RVC....Continue Reading

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Citations

Oct 27, 2015·The Journal of Physiology·Dino A Giussani
Oct 30, 2016·American Journal of Obstetrics and Gynecology·Silvia M LobmaierUNKNOWN TRUFFLE investigators (see Acknowledgments)
Jun 23, 2016·The Journal of Physiology·Christopher A LearAlistair J Gunn
Jan 18, 2017·The Journal of Physiology·Laura Bennet
Feb 7, 2020·Physiological Reports·Tamara J VarcoeJanna L Morrison
Mar 22, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert GalinskyAlistair J Gunn
Sep 1, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A AntolicM Keller-Wood
Sep 3, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher A LearAlistair J Gunn
Sep 3, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher A LearAlistair J Gunn
May 7, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher A LearAlistair J Gunn

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