Renal sympathetic neural mechanisms as intermediate phenotype in spontaneously hypertensive rats

Hypertension
G F DiBonaL L Sawin

Abstract

The borderline hypertensive rat, the F1 of a cross between a hypertensive spontaneously hypertensive rat (SHR) and a normotensive Wistar-Kyoto (WKY) rat, is a NaCl-sensitive model of genetic hypertension. In addition to hypertension, borderline hypertensive rats fed 8% NaCl develop characteristic alterations in the regulation of efferent renal sympathetic nerve activity and the neural control of renal function that are similar to those observed in the SHR parent. Like the normotensive WKY rat parent, borderline hypertensive rats fed 1% NaCl remain normotensive and do not exhibit these alterations in renal sympathetic neural mechanisms. These renal sympathetic neural mechanisms constitute a complex quantitative trait that may represent an intermediate phenotype. They have a plausible pathogenetic role in hypertension and are different between SHR and WKY rats. This study evaluated two aspects of this complex quantitative trait, enhanced renal sympathoexcitation with air-jet stress and enhanced renal sympathoinhibition with guanabenz, as a candidate intermediate phenotype. As neither of these aspects was observed in two-kidney, one clip Goldblatt-hypertensive rats, this suggests that the trait is not secondary to hypertension fro...Continue Reading

References

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Citations

Sep 2, 1998·Progress in Neurobiology·S C Malpas
Apr 27, 2001·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·S C MalpasD E Burgess
Mar 13, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Philip Thomas, Indranil Dasgupta
Oct 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Masanobu YamazatoShuichi Takishita
Oct 9, 2003·Physiological Genomics·Carol MorenoAllen W Cowley
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·O GriskR Rettig
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes

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