PMID: 9187412Apr 1, 1997Paper

Renal threshold for glucose in non-insulin-dependent diabetic patients

Diabetes Research and Clinical Practice
B RuhnauB Thorsteinsson

Abstract

Measurement of glycosuria is still widely used for home monitoring of glycaemia control in non-insulin-dependent diabetes (NIDDM). This method has been criticized because the renal threshold for glucose (RTglu) varies between subjects. In order to evaluate the validity of RTglu by measuring corresponding measurements of blood and urine glucose in NIDDM patients, we studied the blood/urine glucose relationship in 24 NIDDM patients. RTglu estimated from 75 contemporary blood and urine glucose concentrations measured at home by each patient (h-RTglu) was compared with RTglu measured by a hyperglycaemic glucose clamp (c-RTglu). H-RTglu and c-RTglu, being 7.6 mmol/1 (range 5.5-12.4) and 10.3 mmol/1 (6.2-12.3) respectively (P < 0.005), were weakly correlated (R(S) = 0.35, P = 0.15). In conclusion, c-RTglu varies two-fold between NIDDM patients. RTglu detected by home monitored urine and blood glucose determinations underestimates the true RTglu, probably due to the splay phenomenon. However, the method for detection of RTglu used by us seems of clinical relevance, since it reflects the individual blood glucose level at which glucose is detectable in the urine.

References

Apr 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·K G Alberti, F A Gries
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Citations

Jul 3, 1999·Diabetic Medicine : a Journal of the British Diabetic Association·E S KilpatrickG M Addison
Feb 4, 2014·PloS One·Andrea De GaetanoGeltrude Mingrone
Sep 26, 2015·Diabetes, Obesity & Metabolism·Surya Panicker RajeevJohn P H Wilding
Mar 27, 2015·Nephrology·Richard BrunnerUlrike Holzinger
Nov 1, 2005·Diabetes Research and Clinical Practice·Kaberi DasguptaElham Rahme
Jun 18, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Kyle T BaronMatthew Riggs
Jan 5, 2010·Journal of Diabetes Science and Technology·Steven B WatersCharles M Alexander
Nov 23, 2005·Pediatric Clinics of North America·Nicole Glaser
Dec 4, 2003·Intensive Care Medicine·Barbara J PhilipsEmma H Baker
Jun 20, 2019·Medicina·Carlo GarofaloLuca De Nicola
Apr 22, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Klaus RaveEwoud-Jan van Hoogdalem
Aug 31, 2018·Acta Diabetologica·Juan ChenZilin Sun
Feb 9, 2012·Nature Reviews. Endocrinology·Ele Ferrannini, Anna Solini
Jan 23, 2019·Diabetes·Radica Z AlicicKatherine R Tuttle
May 8, 2020·Journal of Diabetes Research·Ricardo Pereira-Moreira, Elza Muscelli
Feb 4, 2021·Porto Biomedical Journal·Rui Fernandes

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