Renal thromboxane A2 synthesis in the Lyon hypertensive rat

Fundamental & Clinical Pharmacology
K L LiuJ Sassard

Abstract

The aim of the present study was to assess the mechanisms by which norepinephrine (NE) increased the synthesis of prostanoids and revealed a hyperactivity of the Thromboxane (Tx) A2 synthase in the Lyon genetically hypertensive (LH) rat kidney. To this purpose, the effects of NE (1.2 x 10(-8) to 9.6 x 10(-7) M) on renal function and prostanoid synthesis were assessed in isolated perfused kidneys following beta-adrenoceptor blockade by sotalol (10(-5)M) and compared to those of equipressor concentration of an alpha 2-adrenoceptor agonist, BHT 933 (3.5 x 10(-4) M) and angiotensin II (AII) (7.7 x 10(-9) M). Kidneys were isolated from eight week-old male LH rats and from their normotensive (LN) and low blood pressure (LL) controls and perfused in a single pass system. In baseline conditions, sotalol did not modify renal function or urinary prostanoids in any of the three strains. Following NE stimulation, it potentiated the increase in renal vascular resistance of LL and LN controls but not that of LH rats. The pressure-natriuresis and the urinary prostanoids remained unchanged. BHT 933 elicited a weak stimulation of prostanoid release while AII markedly increased it and revealed, as did NE, the hyperactivity of the TxA2 synthase. ...Continue Reading

References

Apr 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K L LiuP Zech
Nov 1, 1989·American Journal of Hypertension·N Perico, G Remuzzi
Sep 1, 1980·Journal of Cardiovascular Pharmacology·M Schmidt, J L Imbs
Dec 1, 1983·Journal of Autonomic Pharmacology·K R Borkowski, M Porter
Dec 23, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·D BenzoniJ Sassard

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Citations

Oct 1, 1994·Journal of Biomedical Science·J. Sassard, D. Benzoni
May 21, 2009·Journal of Hypertension·Juan M Saavedra

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