Renal tissue gas tensions during hemorrhagic shock

Journal of Anesthesia
K MurakawaA Kobayashi

Abstract

To evaluate the development of renal hypoxia during hemorrhagic shock, fourteen dogs were induced in this study. The animals were divided equally into a group in which mean arterial pressure (MAP) was kept at 50 mmHg (group 1), and into another where MAP was kept at 40 mmHg for 180 min (group 2). Renal tissue gas tensions were determined by a mass spectrometer. In the 50-mmHg group, renal tissue oxygen tension (PrO2) dropped for 15 min following hemorrhage, remained constant for 90 min, then fell further for 150 min before a plateau was established. In the 40-mmHg group, the PrO2 dropped for 90 min before reaching a plateau. The second PrO2 decline occurred at the same level in both the 50-mmHg group and the 40-mmHg group. The point at which the same PrO2 level occurred for each group suggests the cessation of oxygen consumption and the conditions of renal hypoxia. It is assumed that renal hypoxia occurs in 120 min at a MAP of 50-mmHg and in 60 min at a MAP of 40 mmHg.

References

Mar 1, 1973·American Journal of Surgery·R H Guthrie, R L Cucin
Dec 1, 1971·The American Journal of Physiology·J StraussJ L Reyes-Sanchez
Apr 1, 1966·The American Journal of Physiology·C Fell
Mar 1, 1968·The Journal of Clinical Investigation·K Aukland, M Wolgast
May 1, 1982·Journal of Analytical Toxicology·R B ForneyB Holmstedt
Jan 1, 1962·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·O MUNCKK KRAMER

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.