Renal tissue impedance: responses of the real and imaginary component to experimental variations in medullary electrolytes

Acta Physiologica Scandinavica
J SadowskiS N Rasmussen

Abstract

In order to assess the renal corticomedullary electrolyte gradient, electrical impedance (zeta) and phase angle (phi) were measured in the in-situ kidney of anaesthetized rats. A set of platinum/iridium needle electrodes was used, and the frequency (f) of the measuring current was varied between 0.5 and 50 kHz. zeta and its imaginary component (chi c) fell sharply as f increased from 0.5 to 3.5 kHz, and then decreased slowly or stabilized, whereas the real component (R) decreased progressively over the entire f range. Ion concentration in the renal medulla was experimentally lowered by administration of furosemide or hypertonic mannitol or by inducing a haemorrhage, and raised by infusing hypertonic NaCl solution. Both R and chi c varied inversely with tissue electrolyte concentration. Raising f from 3.5 to 10 and further to 20 kHz did not significantly amplify the changes in zeta. Within this frequency range R was not a more sensitive index of tissue electrolyte changes compared with overall zeta-value. The results verify previous empirical data indicating that changes in medullary tissue electrolytes can be dynamically estimated by monitoring tissue impedance.

References

Nov 1, 1977·Kidney International·M A KnepperR S Post
Aug 1, 1990·Archives internationales de physiologie et de biochimie·B BadzyńskaE Kompanowska-Jezierska
Dec 1, 1984·Archives internationales de physiologie et de biochimie·E Portalska, J Sadowski
Dec 1, 1983·Kidney International·J Sadowski, E Portalska

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Citations

Nov 1, 1991·Pflügers Archiv : European journal of physiology·N ParekhM Steinhausen
Oct 1, 1994·Pflügers Archiv : European journal of physiology·E Kompanowska-JezierskaJ Sadowski
Feb 27, 2003·Clinical and Experimental Pharmacology & Physiology·Janusz Sadowski, Leszek Dobrowolski
Aug 1, 1992·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·L DobrowolskiE Kompanowska-Jezierska

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