Renal tissue Po2 sensing during acute hemodilution is dependent on the diluent

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jessica R AbrahamsonGregory M T Hare

Abstract

Sensing changes in blood oxygen content ([Formula: see text]) is an important physiological role of the kidney; however, the mechanism(s) by which the kidneys sense and respond to changes in [Formula: see text] are incompletely understood. Accurate measurements of kidney tissue oxygen tension ([Formula: see text]) may increase our understanding of renal oxygen-sensing mechanisms and could inform decisions regarding the optimal fluid for intravascular volume resuscitation to maintain renal perfusion. In some clinical settings, starch solution may be nephrotoxic, possibly due to inadequacy of tissue oxygen delivery. We hypothesized that hemodilution with starch colloid solutions would reduce [Formula: see text] to a more severe degree than other diluents. Anesthetized Sprague-Dawley rats (n = 77) were randomized to undergo hemodilution with either colloid (6% hydroxyethyl starch or 5% albumin), crystalloid (0.9% saline), or a sham procedure (control) (n = 13-18 rats/group). Data were analyzed by ANOVA with significance assigned at P < 0.05. After hemodilution, mean arterial pressure (MAP) decreased marginally in all groups, while hemoglobin (Hb) and [Formula: see text] decreased in proportion to the degree of hemodilution. Cardia...Continue Reading

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Citations

Aug 10, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareC David Mazer
Nov 12, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kyle ChinGregory M T Hare
May 20, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Stephanie FranzénRobert Frithiof

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