PMID: 11319297Apr 25, 2001Paper

Renal tolerance to cisplatin in patients 70 years and older

American Journal of Clinical Oncology
A CubilloM González Barón

Abstract

The purpose of this study was to evaluate cisplatin nephrotoxicity in patients 70 years and older and to identify factors influencing nephrotoxicity occurrence. Forty-nine (N = 49) patients older than 70 years were studied retrospectively. All patients received treatment with cisplatin. Variables under study were as follows: prechemotherapy serum creatinine levels (Crb), maximum serum creatinine level during treatment (Crmax), steady serum creatinine level 3 months after treatment completion (Crstb), as well as their corresponding creatinine clearance values (CrbC, CrmaxC, CrstbC) as calculated by the Cockroft and Gault formula. Maximum creatinine increment (Imax = Crmax - Crb), stable creatinine increment (Istb = Crstb - Crb) and the corresponding clearance decrements (Dmax and Dstb) were calculated as well. The potential relationship of the above variables to cisplatin dose intensity and accumulated dose as well as to different prognostic factors were also considered. Assessment of associated conditions was carried out by means of Charlson comorbidity index. The patients' mean age was 73 years (range: 70-79 years). There were 43 men (88%) and 6 women (12%). Mean cisplatin dose intensity was 27 mg/m2/wk. A total of 157 chemoth...Continue Reading

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Citations

Apr 25, 2003·Critical Reviews in Oncology/hematology·Stuart M LichtmanSunitha Vemulapalli
Jul 24, 2003·Drugs & Aging·Veena JohnStuart Lichtman
Nov 11, 2003·Clinical Pharmacokinetics·Hans WildiersAllan T van Oosterom
Sep 16, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·B H AliM O Tanira
Oct 20, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lucio BuffoniOscar Bertetto
May 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stuart M LichtmanUNKNOWN International Society of Geriatric Oncology Chemotherapy Taskforce
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cesare GridelliCorey Langer
Aug 16, 2011·Critical Reviews in Toxicology·Penélope D Sánchez-GonzálezAna I Morales
Jan 24, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Arti Hurria, Stuart M Lichtman
Jun 4, 2020·Therapeutic Advances in Medical Oncology·ZhiYu DuanXiangMei Chen
Mar 7, 2020·International Journal of Preventive Medicine·Mohammad Reza TamadonRaheb Ghorbani

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